1989 Fiscal Year Final Research Report Summary
Low-dose-rate teletherapy combined with hyperthermia as a boost therapy
| Project/Area Number |
62570468
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAI Yoshihiro TOHOKU UNIVERSITY HOSPITAL, Dep. of Radiology, Lecturer, 医学部附属病院, 講師 (50107653)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Yoshihiro TOHOKU UNIVERSITY HOSPITAL, Dep. of Radiology, Staff, 医学部附属病院, 助手 (00169202)
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| Project Period (FY) |
1987 – 1989
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| Keywords | Advanced cancer / Radiotherapy / Low dose rate teletherapy / Hyperthermia / Metastasis |
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| Research Abstract |
The efficacy of the low dose rate teletherapy ( LDRT ; 1 Gy/hr, 4 Gy/day, 2-3 times/week) combined with hyperthermia as a boost therapy ( H(+) group ) against far advanced carcinomas was examined. The results of H (+) group ( 20 esophageal carcinomas, 7 panergatic and bile duct carcinomas, and 7 other carcinomas ) were compared with the ones of H(-) group ( 46 esophageal carcinomas, 7 pancreatic and bile duct carcinomas, 10 colon carcinomas and 15 other carcinomas ) which were treated with LDRT ( 1 Gy/hr, 7 Gy/day, every day ) as a boost therapy. A total dose of 14-24 Gy by LDRT was followed after the irradiation of 50-60 Gy by conventionally fractionated method ( 1.5-2 Gy/day ).
H(+) cases were treated with 42.5ﾟC, 1 hour hyperthermia immediately before LDRT and 22 cases ( 65% ) were successfully heated. There was no significant difference between H(+) group and H(-) group in local control rates, late severe complication rates and survival rates, even when they were corrected by primary sites and stages. The incidence of metastases was a little higher in H(+) group.
It was considered that the gain of the combination of LDRT and hyperthermia was not so high.
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Research Products
(10 results)
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[Publications] Yamada, S., Takai, Y., Ogawa, Y., Abe, H., Satou, A., Sugita, R., Yamazaki, T. and Sakamoto, K.: "The prognostic significance of an esophageal carcinoma according to various irradiation methods." Jpn. J. Cancer Clin. 35(1):25-29, 1989.
Description
「研究成果報告書概要(欧文)」より
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