• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1989 Fiscal Year Final Research Report Summary

Low-dose-rate teletherapy combined with hyperthermia as a boost therapy

Research Project

Project/Area Number 62570468
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

TAKAI Yoshihiro  TOHOKU UNIVERSITY HOSPITAL, Dep. of Radiology, Lecturer, 医学部附属病院, 講師 (50107653)

Co-Investigator(Kenkyū-buntansha) OGAWA Yoshihiro  TOHOKU UNIVERSITY HOSPITAL, Dep. of Radiology, Staff, 医学部附属病院, 助手 (00169202)
Project Period (FY) 1987 – 1989
KeywordsAdvanced cancer / Radiotherapy / Low dose rate teletherapy / Hyperthermia / Metastasis
Research Abstract

The efficacy of the low dose rate teletherapy ( LDRT ; 1 Gy/hr, 4 Gy/day, 2-3 times/week) combined with hyperthermia as a boost therapy ( H(+) group ) against far advanced carcinomas was examined. The results of H (+) group ( 20 esophageal carcinomas, 7 panergatic and bile duct carcinomas, and 7 other carcinomas ) were compared with the ones of H(-) group ( 46 esophageal carcinomas, 7 pancreatic and bile duct carcinomas, 10 colon carcinomas and 15 other carcinomas ) which were treated with LDRT ( 1 Gy/hr, 7 Gy/day, every day ) as a boost therapy. A total dose of 14-24 Gy by LDRT was followed after the irradiation of 50-60 Gy by conventionally fractionated method ( 1.5-2 Gy/day ).
H(+) cases were treated with 42.5゚C, 1 hour hyperthermia immediately before LDRT and 22 cases ( 65% ) were successfully heated. There was no significant difference between H(+) group and H(-) group in local control rates, late severe complication rates and survival rates, even when they were corrected by primary sites and stages. The incidence of metastases was a little higher in H(+) group.
It was considered that the gain of the combination of LDRT and hyperthermia was not so high.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 山田章吾: "Boost therapyとしての低線量率遠隔照射法(第2報)問題点" 日本医学放射線学会雑誌. 48. 65-71 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 細井義夫: "子宮頸癌用RF波腔内アプリケ-タの改良とその臨床応用" 日本ハイパ-サ-ミア学会誌. 4. 207-214 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山田章吾: "食道癌の放射線治療成績-照射法による予後の差-" 癌の臨床. 35. 25-29 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada,S.: "Radiotherapy for malignant fistula to other tract." Cancer. 64. 1026-1028 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山田章吾: "Boost therapyとしての低線量率遠隔照射法(第3報)温熱療法との併用" 日本医学放射線学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada, S., Takai, Y., Takahashi, T. and Sakamoto, K.: "Low dose rate teletherapy as boost therapy. (2) Its problems." Nippon Acta Radiologica 48(1):65-71, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosoi, Y., Yamada, S., Takai, Y., Ogawa, Y. and Sakamoto, K.: "A new intracavitary RF applicator for uterine cervical cancer and its clinical indication." Jpn. J. Hyperthermic Oncol. 4(3):207-214, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, S., Takai, Y., Ogawa, Y., Abe, H., Satou, A., Sugita, R., Yamazaki, T. and Sakamoto, K.: "The prognostic significance of an esophageal carcinoma according to various irradiation methods." Jpn. J. Cancer Clin. 35(1):25-29, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, S., Takai, Y., Ogawa, Y., Kakuto, Y. and Sakamoto, K.: "Radiotherapy for malignant fistula to other tract." Cancer 64(5):1026-1028, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada, S., Takai, Y., Ogawa, Y., and Sakamoto, K.: "Low dose rate teletherapy as a boost therapy (3) Combination with hyperthermia." Nippon Acta Radiologica.

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi