1988 Fiscal Year Final Research Report Summary
Chemical Pathology of Receptors in Autopsied Brains of Patients with Schizophrenia
Project/Area Number |
62570489
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Kobe University |
Principal Investigator |
MITA Tatsuo Dept. of Psychiatry and Neurology Kobe Univ. Faculty of Medicine Research Associ, 医学部, 助手 (70127405)
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Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Kenji Dept. of Psychiatry and Neurology Kobe Univ. Hospital, Research Associate, 医学部附属病院, 助手 (40163638)
NAKAI Hisao Dept. of Psychiatry and Neurology Kobe Univ. Faculty of Medicine Proffessor, 医学部, 教授 (50094389)
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Project Period (FY) |
1987 – 1988
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Keywords | Human brain / Schizophrenia / Dopamine uptake / ^3H-GBR-12935 binding sites / Histamine receptor / ^3H-Mepyramine binding sites / フェンサイクリジン結合部位 |
Research Abstract |
We have investigated the alterations of dopamine uptake sites, histamine H_1 receptors and phencyclidine binding sites in the postmortem brain samples from patients with chronic schizophrenia, using [^3H]GBR-12935, [^3H]mepyramine and [^3H]1-[1-(2-thienyl)cyclohexyl]piperidine ([^3H]TCP) as a respective radioligand. 1. The binding sites for [^3H]GBR-12935, a selective dopamine uptake inhibitor, tended to increase in the putamen of patients with schizophrenia as compared with age-matched control subjects, although the difference between the means was not statistically significant. 2. The binding sites for [^3H]mepyramine, a selective histamine H_1 receptor antagonist, were identified in the human brain, and they were significantly decreased by 35 % in the frontal cortex of patients with schizophrenia. 3. The phencyclidine binding sites labeled by [^3H]TCP, which were considered to be coupled with N-methyl-D-aspartate (NMDA)-sensitive L-glutamate receptors, were shown to be influenced by L-glutamate, glycine and Mg^<2+> in the human brain, as demonstrated in other mammals. There were no significant chenges in the specific [^3H]TCP binding in the frontal cortex or hippocampus of patients with schizophrenia.
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[Publications] Hirai, M.; Kitamura, N.; Hashimoto, T.; Nakai, T.; Mita, T.; Shirakawa, O.; Yamadori, T.; Amano, T.; Noguchi-Kuno, S.; Tanaka, C.: "[^3H]GBR-12935 binding sites in human striatal membranes: Binding characteristics and changes in Parkinsonians and schizophrenics" Japanese Journal of Pharmacology. 47. 237-243 (1988)
Description
「研究成果報告書概要(欧文)」より
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