1988 Fiscal Year Final Research Report Summary
Experimental Study of Intralymphatic Chemotherapy in Rabbits.
| Project/Area Number |
62570577
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | SAITAMA MEDICAL SCHOOL |
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Principal Investigator |
SATOMI Akira Saitama Medical School, Associate Professor, 医学部, 助教授 (50105912)
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| Project Period (FY) |
1987 – 1988
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| Keywords | Intralymphatic Chemotherapy / 高分子量制癌剤 |
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| Research Abstract |
In order to examine the clinical usefulness of intralymphatic chemotherapy and the regimen of the appropriate anticancer drug for this route, we measured serum and tissue drug levels following intralymphatic administration of futraful (FT) or neocarzinostatin (NCS) in rabbits with VX2 carcinoma and their control.
The results were as follows; 1) when a low - molecular - weight drug such as FT was administered into the lymphatic vessels, most of the drug flowed into the systemic circulation through the thoracic duct, but some leaked from the lymphatic vessels and flowed into the portal vein via the intestine. 2) In the case of high - molecular - weight drug such as NCS, there was a tendency for it to remain in the lymph nodes. 3) It i therefore seems that a drug of high - molecular - weight is most suitable for use in intralymphatic administration. 4) In metastatic lymphnode, tissue level of NCS in intralymphatic group showed high concentration than in intravenous group. 5) It seems that intralymphatic administration do not depend upon the degree of metastase.
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