1989 Fiscal Year Final Research Report Summary
Cancer and Amino acid metabolism - Effect of total parenteral nutrition (TPN) with arginine imbalanced solution on the growth of Yoshida sarcoma.
| Project/Area Number |
62570583
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HATANO Takehiko Kansai Medical University, Lecturer, 医学部, 講師 (50077731)
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| Co-Investigator(Kenkyū-buntansha) |
ASAO Yasunobu Kansai Medical University, assistant, 医学部, 助手 (00175829)
NISHI Masaharu Kansai Medical University, assistant, 医学部, 助手 (90164532)
HIOKI Koshiro Kansai Medical University, assistant professor, 医学部, 助教授 (60077641)
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| Project Period (FY) |
1987 – 1988
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| Keywords | Cancer / Amino acid metabolism / Arginine imbalance |
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| Research Abstract |
The effect of total parenteral nutrition (TPN) with arginine imbalanced solution containing enriched branched chain amino acids(TEO-10) on the growth of Yoshida sarcoma was examined in tumor-bearing Donryu rats.
Arginine contents in TEO-10, and AI-I,II and III were 1,050g/dl, 3,050g/dl, 5,000g/dl, and 7,000g/dl, respectively. The rats were infused for 8 days via TPN route with each arginine imbalanced solution and then sacrificed.
The body weight gain in the AI-II group was better than those in the TEO-10, AI-I and III groups. The tumor growth was also significantly suppressed in the AI-II group.
The arginine and ornithine concentrations in the serum, urine and tumor tissue in the AI groups were significantly higher than that in the TEO-10 group.
These results suggest that TPN with AI-II solution, which is equivalent to 5 % arginine imbalanced solution, has significant inhibitory effects on the growth of Yoshida sarcoma.
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