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1988 Fiscal Year Final Research Report Summary

Reseach for antithrombogenic therapy and diagnostic methods of thrombosed valve after prosthetic heart valve replacement

Research Project

Project/Area Number 62570632
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNiigata University School of Medicine

Principal Investigator

EGUCHI Syoji  Niigata University School of Medicine, Professor, 医学部, 教授 (90018367)

Co-Investigator(Kenkyū-buntansha) 斉藤 憲  新潟大学, 医学部付属病院, 医員
藤田 康雄  新潟大学, 医学部付属病院, 医員
NAKAZAWA Satoshi  Niigata University School of Medicine, Clinical fellow, 医学部付属病院, 医員
TSUCHIDA Syoichi  Niigata University School of Medicine, Clinical fellow, 医学部付属病院, 医員 (20227383)
HAYASHI Jun-ichi  Niigata University School of Medicine, Assistant, 医学部, 助手 (30164940)
FUJITA Yasuo  Niigata University School of Medicine, Clinical fellow
SAITO Akira  Niigata University School of Medicine, Clinical fellow (40251821)
Project Period (FY) 1987 – 1988
KeywordsThromboembolism / Antiplatelet therapy / Platelet aggregability / Thrombosed valve / St.Jude Medical valve / 人工弁閉鎖音周波数スペクトラム特性
Research Abstract

The results of our investigation were as follows;
1. Clinical comparative study between anticoagulant therapy with antiplatelet therapy and without one was undergone for patients who had been endured St.Jude Medical prosthetic heart valve replacement at mitral position from 1980 to Jan 1989. Thromboembolic episodes had occurred more frequently in anticoagulant group without antiplatelelt therapy (1.38%/patient-year) than in with antiplatelet therapy (0%/patient-year). But no significance (p value; more than 0.05) was seen between these groups.
2. Platelet aggregability after prosthetic valve replacement was estimated at early postoperative stage and chronic out-patient phase administrated oral antiplatelet drugs. homologous blood transfusion during operation depressed platelet aggregability and prolonged depressive one. Administration of small dose of antiplatelet (Ticlopidine 100-300mg/day and Aspirin 0-30mg/day) sufficiently depressed platelet function and seemed safe from haemorrhagic complications and thromboembolic episodes.
3.^<111>in-oxine labeled platelet scincigraphy seemed worth to detect non-clinical thrombosed prosthetic valves and to estimate thrombogenic activity of patients with heart valve replacement.
4. The frequency spectra of normal SGM cardiac prostheses had a peak at 1.2KH_z, and decline the power gradually as incresing their frequency at aortic position. Each of an obvious thrombosed SJM valve and two malfunctinal SJM prostheses had a profound dip around 2.5KH_z at aortic or pulmonic position, which would give us useful information about non-clinical thrombosed prosthetic valve.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 藤田康雄 他: 人工臓器. 16. 259-262 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中沢聡 他: 日本心臓血管外科学会雑誌. 17. 177-179 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamura Haruo,et al.: J.Thoracic Cardiovascular Surgery. 94. 148-150 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中沢聡 他: 日本心臓血管外科学会雑誌. 16. 498-500 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤田康雄 他: 人工臓器. 17. 1133-1136 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤田康雄 他: 人工臓器. 18. 694-697 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujita, Yasuo et al: "Long-term results of Starr-Edwards ball valve Model 1200 and 1260" Jpn. J. Artif. Organs. 16. 259-262 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa, Satoshi et al: "Indium-111-oxine labeled platelet scincigraphy for detection of thrombosed valves" Jpn. J. Cardiovasc. Surgery. 16. 498-500 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyamura, Haruo et al: "Thrombosed St.Jude Medical valve prosthesis in the right side of the heart in patients with tetralogy of Fallot" J. Thorac. Cardiovasc. Sugery. 94. 148-150 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujita, Yasuo et al: "Frrequency spectrum of SJM cardiac prosthetic closing sound" Jpn. J. Artif. Organs. 18. 694-697 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujita, Yasuo et al: "Has antithrombogenisity of mechanical valve prosthesis been improved?" Jpn. J. Artif. Organs. 17. 1133-1136 (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20   Modified: 2017-04-05  

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