1988 Fiscal Year Final Research Report Summary

The endogenous growth and angiogenesis factor in the placenta and the placental bed.

Research Project

Project/Area Number	62570747
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Yamanashi Medical School
Principal Investigator	YASUMIZU Takehiko Associated Professor, Yamanashi Medical School, 医学部, 助教授 (80107705)
Project Period (FY)	1987 – 1988
Keywords	Angiogenesis factor / growth factor / placental bed / 胎盤 / 卵巣 / DHAS負荷テスト
Research Abstract	Rapid neovasculaization (angiogenesis) takes place in the placental bed of the uterus and the placenta during pregnancy. Whereas the structural components of uterine and placental angiogenesis have been studied extensively, the mechanisms by which these new blood vessels arise are still poorly understood. In this study, I have employed in vitro assay to investigate whether these tissues possess growth and angiogenesis activities. The results demonstrate the presence of factors that stimulate prolieration of mouse BALB/C 3T3 cells and cultured bovine capillary endothelial cells. These actieties are present in extracts of myometrium, placental bed and placenta of the pregnant rat as well as human placenta.