A Histopathological Study on the Effect of Indomethacin on Bone Resorption in an Experimental Apical Periodontitis

1988 Fiscal Year Final Research Report Summary

• Project/Area Number: 62570857
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Kyushu University
• Principal Investigator: ANAN Hisashi Kyusyu University, Faculty of Dentistry Hospital, Assistant, 歯学部付属病院, 助手 (80158732)
• Co-Investigator(Kenkyū-buntansha): YOSHIMINE Yoshito Kyushu University, Faculty of Dentistry Hospital, Assistant, 歯学部付属病院, 助手 (80183705) ; HASHIGUCHI Isamu Kyushu University, Faculty of Dentistry, Assistant, 歯学部, 助手 (10150476)
• Project Period (FY): 1987 – 1988
• Keywords: Indomethacin / Bone resorption / Apical periodontitis / Osteoclast / Acid phosphatase / 骨芽細胞 / アルカリフォスファターゼ / カップリング現象

Research Abstract

The effect of indomethacin (10mg/Kg/day) on bone resorption was investigated on an experimental apical periodontitis induced in wistar strain rats. Indomethacin reduced the extent of resorption surface, the number of osteoclasts, and the number of non-specific acid phosphatase (ACP) positive cells. ACP activity in the osteoclasts was decreased considerably. In addition, the infiltration of polymorphonuclear leucocytes in the apical periodontal ligament was hardly seen after the administration of Indomethacin. But the extent of formation surface was significantly increased. These results suggest that the relationship between bone resorption and formation in apical periodontis is a coupling phenomenon, and PG may stimulate osteoclastics bone resorption.