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1988 Fiscal Year Final Research Report Summary

Non-operative therapeutic approach for cancer in deep abdomen by the control using ultrasonic frequency cepstrum analysis and infra-red light analysis.

Research Project

Project/Area Number 62870029
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionOsaka University

Principal Investigator

KAMADA Takenobu  Professor, Department of Medicine, Osaka University Medical School, 医学部, 教授 (80028399)

Co-Investigator(Kenkyū-buntansha) 笠原 彰紀  大阪大学, 医学部附属病院, 医員
MATSUMURA Takakatsu  Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (90183615)
KAWANO Sunao  Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (60133138)
FUSAMOTO Hideyuki  Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (90124776)
SATO Nobuhiro  Associate professor Department of Medicine, Osaka University Medical School, 医学部, 講師 (90028358)
MEREN Haruya  Assistant professor Department of Medicine, Osaka University Medical School
Project Period (FY) 1987 – 1988
KeywordsUltrasonic frequency-cepstrum analysis / Infrared light analysis / non-operative therapy for cancer / htperthermia / fiber bundle / ケプストラム解析 / 肝癌
Research Abstract

The aim of this investigation is to develope a non-operative, hyperthermia system for cancer treatment with continuous monitoring of cancer tissue by ultrasonic frequency-cepstrum analysis and infra-red light analysis. For this purpose, we introduced a radio-frequency type hyperthermia system and monitored the tissue temperature by Cu-constantan thermocouple. Simultaneously, we developed (1) an infra-red monitoring system for tissue hemodynamics and tissue oxygenation using a thin optical fiber and 2) a ultrasonic frequency-cepstrum system for morphological analysis of hepatic lobules. The former enabled to estimate the oxygenation level of local tissue, thereby determining the local functional change following hyperthermic reaction. The latter was applied to chronic liver diseases including hepatocellular carcinoma, and afforded non-invasive, objective informations as to pathological changes of microstructures of hepatic tissue: cancer tissue showed a wide histogram of average distance of scatters in the liver, thereby differenciating the cancerous region from cirrhosis. Hyperthermia induced an increase of blood flow in normal tissue rather homogeneously, but quite heterogenously in the imjured tissues. Oxygenation level also changed heterogenously in the latter tissue, which resulted in tissue derangement and could be monitored by ultrasonic frequency-cepstrum analyzing system. The combination of the instrument for advanced cancers.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Sato N;Tsuji S;Kawano S;Matsumura T; Kamada T.: Microcirculation-an update. 2. 437-440 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato N;Matsumura T;Kawano S;Kamada T.: Microcirculation-an update. 2. 309-312 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawano S;Sato N;Eguchi H;Tsuji S;Matsumura T;Kamada T.: Biochemical and social aspects of alcohol and alcoholism.367-370 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤信絋、川野淳、辻晋究、鎌田武信: 日本レーザー医学会誌. 9. 15-19 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野通一、佐々木裕、笠原彰紀、八島俊、片山和宏、目連晴哉、古沢俊一、房本英之、佐藤信絋、鎌田武信: 日本超音波医学会講演論文集. 287 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野通一、鈴木郁夫、佐々木裕、林紀夫、笠原彰紀、房本英之、佐藤信絋、鎌田武信: 日本超音波い医学会講演論文集. 47 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato N;Kawano S;Matsumura T;Yoshihara H;Hijioka T;Eguchi H;Kamada T.: "Microcirculation in circulatory disor ders." Springer-Verlag, 215-220 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河野通一、佐々木裕、林紀夫、笠原彰紀、目連晴哉、片山和宏、古沢俊一、八島俊、房本英之、佐藤信絋、鎌田武信: "肝腫瘍の画像診断-その進歩と今後の動向-" メヂカルトリビューン, 20-22 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato, N.; Tsuji, S.; Kawano, S.; Matsumura, T.; Kamada, T.: "Imaging and computer assisted analysis of gastric and hepatic microcirculation." Microcirculation-an update. 2. 434-440 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, N.; Matsumura, T.; Kawano, S.; Kamada, T.: "Hepatic microcirculation and hepatic cellular metabolism" Microcirculation-an update. 2. 302-312 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano, S.; Sato, N.; Eguchi, H.; Tsuji, S.; Matsumura, T.; Kamada, T.: "Visible and infrared spectrophotometry of tissue and organ" Biomedical and Social Aspects of Alcohol and Alcoholism (Elsevier Science Publishers, Tokyo). 367-370 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, N.; Kawano, S.; Fukuda, M.; Kamada, T.: "The effects of a prostaglandin E1 analogue, misoprostol, on gastric mucosal blood volume index and homogloibn oxygen saturation in humans" J. Gastroenterology and Hepatology. 2. 499-505 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, A.; Sato, N.; Matumura, T.; Eguchi, H.; Takei, Y.; Kawano, S.; Kamada, T.: "Regional hepatic tissue oxygenation and bile flow in rats" Cytoprotection and Cytobiology. 4. 83-88 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, N.; Kawano, S.; Matsumura, T.; Yoshihara, H.; Hijioka, T.; Eguchi, H.; Kamada, T.: Role of hepatic microcirculation in the pathogenesis and development of alcoholic liver disease- possible involvement of hypercathecholaminemia. Soringer-Verlag (Tokyo), 215-220 (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-12-19  

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