1989 Fiscal Year Final Research Report Summary
RESEARCH FOR COMBINED THERAPY WITH INTERSTITIAL MACROWAVE HYPERTHERMIA AND INTERSTITIAL IRRADIATION FOR MALIGNANT BRAIN TUMORS
| Project/Area Number |
62870057
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
NISHIMOTO Akira OKAYAMA UNIVERSITY MEDICAL SCHOOL PROFESSOR, 医学部, 教授 (50032850)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Tetsuya OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
MATSUMI Nobuhiko OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
MORIYAMA Eiji OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
MATSUMOTO Kengo OKAYAMA UNIVERSITY MEDICAL SCHOOL ASSISTANT, 医学部, 助手 (10190521)
FURUTA Tomohisa OKAYAMA UNIVERSITY HOSPITAL ASSISTANT, 医学部・附属病院, 助手 (30181457)
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| Project Period (FY) |
1987 – 1989
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| Keywords | INTERSTITIAL IRRADIATION / MICROWAVE INTERSTITI / HYPERTHERMIA / HYPERTHERMIA / BRAIN TUMOR / ^<192>Ir SEED / CT-GUIDED STEREOTACTIC SYSTEM |
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| Research Abstract |
1) Interstitial Irradiation
To investigate the effects of interstitial irradiation on normal brain tissue, Ir-192 seeds were stereotactically implanted into the cerebral hemisphere of adult Japanese monkeys. The effects on the brain were evaluated with neurological examination, neuroradiography and histological examination. Significant damage such as necrosis was observed on the area irradiated more than 200-260 Gy. The radiation-induced edema was most prominently observed in the acute stage and thereafter decreased gradually up to 6 months. The further researchs were necessary to determine the relative contributions of dose rate, total, dose, irradiated volume.
2) Interstitial Hyperthermia
The theramal damage of normal brain tissure was estimated from the immediate and delayd histological changes caused by microwave intersititial hyperthermia. A microwave antenna within a cooling system was inserted into the cerebral hemisphere. The temperature at a reference point was maintained at 42,4
… More
3,44,45 and 46ﾟC for 60 minutes. Areas heated below 44ﾟC showed no obvious irreversible change and areas heated at 44ﾟC or above showed coagulative necrosis. Those histological findings indicate that the thermal damage occurs after at 44ﾟC or above for 60 minutes, and suggest that the safety limit for brain hyperthermia is 43ﾟC for 60 minutes.
3) Clinical Trial
Eleven patients with recurrent or unremovable malignant brain tumors were treated by interstitial irradiation with 192Ir seeds using BRW stereotactic systems. Two patients also recieved the interstitial hyperthermia in combination with interstitial iiradiation. In one patient, the tumor had disappeard, and tumor regression was observed in 5 patients of the 11 patients. The results suggest that interstitial irradiation and hypertermia are useful for malignant brain tumors. However, in this study the small numbers and short follow-up preclude any conclusions regarding efficacy. Additional clinical and basic research should be obtained to determine the value of interstitial irradiation and hyperthermia in th treatment of malignant brain tumors. Less
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