• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1990 Fiscal Year Final Research Report Summary

Information Exchange on Cancer Research with North American Countries

Research Project

Project/Area Number 63042001
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionThe Institute of Medical Science, The University of Tokyo

Principal Investigator

YAMAGUCHI Nobuo  The Institute of Medical Science, The University of Tokyo, 医科学研究所・ウイルス研究部, 教授 (90012723)

Co-Investigator(Kenkyū-buntansha) KUCHINO Yoshiyuki  National Cancer Center Research Institute, 部長 (60124418)
UEDA Tooru  Faculty of Pharmacology, Hokkaido University, 薬学部, 教授 (20113524)
ITO Yoshiaki  Institute of Virus Research, Kyoto University, ウイルス研究所, 教授 (80004612)
TAKEICHI Masatoshi  Faculty of Science, Kyoto University, 理学部, 教授 (00025454)
IBA Hideo  The Institute of Medical Science, The University of Tokyo, 医科学研究所・癌ウイルス研究部, 助教授 (60111449)
YOSHIDA Michihiro  Faculty of Science, Hokkaido University, 理学部, 教授 (60001765)
KATAGIRI Takuya  The Institute of Medical Science, The University of Tokyo, 医科学研究所・免疫学研究部, 助手 (70126100)
TANIGUCHI Tadatsugu  Institute of Molecular and Cellular Biology, Osaka University, 細胞工学センター・遺伝子情報研究部門, 教授 (50133616)
HANDA Hiroshi  Faculty of Medicine, The University of Tokyo, 医学部, 助教授 (80107432)
FUJIWARA Hiromi  School of Medicine, Osaka University, 医学部, 助教授 (70116094)
KANNAGI Reiji  Faculty of Medicine, Kyoto University, 医学部, 講師 (80161389)
YAMASHINA Ikuo  Faculty of Pharmacology, Kyoto University, 薬学部, 教授 (70025675)
MATSUBARA Ken-ichi  Institute for Molecular and Cellular Biology, Osaka University, 細胞工学センター, 教授 (20037394)
YAMAMOTO Naoki  School of Medicine, Yamaguchi University, 医学部, 教授 (00094053)
MIYATA Takashi  Faculty of Science, Kyusyu University, 理学部, 助教授 (20022692)
KATO Ryuichi  School of Medicine, Keio University, 医学部, 教授 (40112685)
YUASA Yasuhito  School of Medicine, Tokyo Medical and Dental University, 医学部, 教授 (80111558)
YAMAMOTO Tadashi  The Institute of Medical Science, The University of Tokyo, 医科学研究所・制癌研究部, 助教授 (40134621)
HINO Shigeo  School of Medicine, Nagasaki University, 医学部, 助教授 (70012763)
NAGASAWA Hiroshi  Faculty of Agriculture, Meiji University, 農学部, 教授 (10076987)
NOSE Kiyoshi  The Institute of Medical Science, The University of Tokyo, 癌細胞学研究部, 助教授 (70012747)
KAWAI Sadaaki  The Institute of Medical Science, The University of Tokyo, 癌ウイルス研究部, 教授 (70107423)
FUJIKI Hirota  National Cancer Center Research Institute, 部長 (60124426)
KUROKI Toshio  The Institute of Medical Science, The University of Tokyo, 癌細胞学研究部, 教授 (90006073)
MONDEN Takushi  School of Medicine, Osaka University, 医学部, 助手 (20174477)
TSURUO Takashi  The Institute of Applied Microbiology, The University of Tokyo, 応用微生物研究所, 教授 (00012667)
NAKAMURA Toshikazu  Faculty of Science, Kyushu University, 理学部, 教授 (00049397)
TSUKITA Shouichiro  National Institute for Physiological Science, Okazaki National Institutes, 生理学研究所, 教授 (50155347)
UEDE Toshimitsu  Dept. Pathology, Sapporo Medical College, 病理学第一講座, 助教授 (00160185)
SUGAMURA Kazuo  School of Medicine, Tohoku University, 医学部, 教授 (20117360)
YOSHIKE Kunito  National Institute of Health, Japan, 腸内ウイルス部, 室長 (90072925)
KIKUCHI Kunimi  Institute of Immunological Science, Hokkaido University, 免疫科学研究所, 教授 (20006117)
MARUHASHI Akira  School of Medicine, The University of Tsukuba, 臨体医学系, 講師 (30114135)
SHIBUYA Masabumi  The Institute of Medical Science, The University of Tokyo, 医科学研究所・細胞遺伝学研究部, 教授 (10107427)
NOMURA Nobuo  Institute of Gerontology, Nippon Medical School, 助教授 (20147862)
HATTORI Seisuke  National Institute of Neuroscience, NCNP, 神経研究所・診断部, 室長 (50143508)
Project Period (FY) 1988 – 1990
KeywordsOncogene / Viral Oncogene / Tumor Promoter / Tumor Supressor Gene / Tumor Antigen / T Cell Growth / Immune Desponse / Lymphokine
Research Abstract

This research project is to exchange information between groups of high research activity in Japan and those in North American countries.
The research fields of this project are as follows.
1. Oncogene research
2. Viral Oncogenesis
3. Tumor promotion and suppression
4. Diagnostic techniques and cancer therapy
5. Mechanism of immune regulation and immune regulatory substances
Under this program from 1989 to 1991 fiscal year, total 39 Japanese scientists were sent to United State of America and Canada to attended the oncogene meeting, Gordon conference, hepatitis B virus meeting, the molecular diagnostics of human cancer, the meeting on biological safety standard, UCLA symposium, the meeting on human gene mapping, symposium on active metabolic intermediates, the meeting on origins of human cancer, DNA tumor virus meeting, lymphokine workshop, American society of immunology, the meeting on hepatic regeneration and carcinogenesis, Japan-US histochemistry meeting, the joint-meeting of American societies of biochemistry, molecular biology, and immunology, and also visited universities and institutes to exchange information.
Scientists in Japan, which is geologically remote from developed countries, feel informational retardation. International cooperative studies in progress or in planning, need lively discussions and cautious experimental arrangements. Face-to-face discussions also facilitate international exchange of research materials. Therefore, this research grant contributed greatly not only for the development of the research of the Japanese grant recipients but also for the development of the research of those who came into touch with them.
The individual results under this program have been published in scientific journals, and a part of the informations were also published on the "Bioscience News".

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Kim,D.W.(Yamaguchi,N.): "Use of the human elongation factor 1α promotor as a versatile and efficient expression system" Gene. 91. 217-223 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] EspinozaーDelgado,I.(Sugamura,K.): "Expression and role of p75 interleukin 2 receptor on monocytes" J.Exp.Med.171. 1821-1826 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Voss,S.D.(Sugamura,K.): "Increased expression of the ILー2 receptor β chain (p70) on CD56^+ NK cells following in vivo ILー2 therapy: p70 expression dose not alone predict the level of intermediateーaffinity ILー2 binding" J.Exp.Med.172. 1101-1114 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ekberg,S.(Nakamura,T.): "Growth hormone advances the initiation of hepatocyte growth factor gene expression and DNA synthesis in rat liver after partial hepatectomy" Endocrinology. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hamada,H.(Tsuruo,T.): "Mouseーhuman chimeric antibody against the multidrug trasporter pーglycoprotein" Cancer Res.50. 3167-3171 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Harada,H.(Taniguchi,T.): "Absence of the type 1 IFN system in EC cells: Transcriptional activator (IRFー1) and repressor (IRFー2) genes are developmentally regulated" Cell. 63. 303-312 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hattori,S.: "Identification of NF1 gene product" Nature,submitted.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsushime,H.(Shibuya,M.): "A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis" Mol.Cell.Biol.10. 2261-2268 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura,K.(Kikuchi,K.): "Effect of hepatocarcinogenesis on gene expression of protein phosphatases" in preparation.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe,S.(Yoshiike,K.): "Mutational analysis of human papillomavirus type 16 E7 functions" J.Virol.64. 207-214 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanda,T.(YoshiiKe,K.): "Two immunodominant regions of the human papillomavirus type 16 E7 protein are masked in the nuclei of monkey COSー1 cells" submitted for publication.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] WeilーHillman, G. (Sugamura, K.): "Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (Tac) negative phenptype" Cancer Res.50. 2683-2691 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinebuchi, M. (Uede, T.): "A novel cell surface antigen involved in thymocyte and thymic epithelial cell adhesion" submitted for publication.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato, N. (Tsukita, S.): "Radixin, a barbedーendーcapping actinーmodulating protein, is concentrated at the cleavage furrow during cytokinesis" J. Cell Biol.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bhargava, K. (Nakamura, T.): "Scatter factor and hepatocyte growth factor: Comparison of biologic activities and immunologic activity" J. Biol. Chem.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawasaki, Y. (Monden, T.): "Immunohistochemical study of p53 expression in microwaveーfixed paraffin sections of colorectal carcinomas and adenoma" Am. J. Clin. Pathol.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuzawa, A. (Katagiri, T.): "A new allele of lpr locus, lpr^<cg>, that complements the gld gene in induction of lymphadenopathy in the mouse" J. Exp. Med.171. 519-531 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim, D. W. (Yamaguchi, N.): "Use of the human elongation factor alpha promoter as a versatile and efficient expression system" Gene. 91. 217-223 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hattori, S.: "Identification of NF1 gene product" Nature.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushime, H. (Shibuya, M.): "A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis" Mol. Cell. Biol.10. 2261-2268 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura, K. (Kikuchi, K.): "Effect of hepatocarcinogenesis on gene expression of protein phosphatases"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, S. (Yoshiike, K.): "Mutational analysis of human papillomavirus type 16 E7 functions." J. virol.64. 207-214 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanda, T. (Yoshiike, K.): "Two immunodominant regions of the human papillomavirus type 16 E7 protein are masked in the nuclei of monkey COS-1 cells"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Espinoza-Delgado, I. (Sugamura, K.): "Expression and role of p75 interleukin 2 receptor on monocytes" J. Exp. Med.171. 1821-1826 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Weil-Hillman, G. (Sugamura, K.): "Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (Tac) negative phenotype" Cancer Res.50. 2683-2691 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Voss, S. D. (Sugamura, K.): "Increased expression of the IL-2 receptor beta chain (p70) on CD56 ^+NK cells following in vivo IL-2 therapy : p70 expression dose not alone predict the level of intermediate-affinity IL-2 binding" J. Exp. Med.172. 1101-1114 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinebuchi, M. (Uede, T.): "A novel cell surface antigen involved in thymocyte and thymic epithelial cell adhesion"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, N. (Tsukita, Sh.): "Radixin, a barbed-end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis" J. Cell. Biol.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ekberg, S. (Nakamura, T.): "Growth hormone advances the initiation of hepatocyte growth factor gene expression and DNA synthesis in rat liver after partial hepatectomy" Endocrinology. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bhargava, M. (Nakamura, T): "Scatter factor and hepatocyte growth factor : Comparison of biologic activities and immunologic activity" J. Biol. Chem.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamada, H. (Tsuruo, T.): "Mouse-human chimeric antibody against the multidrug trasporter P-glycoprotein" Cancer Res.50. 3167-3171 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawasaki, Y (Monden, T.): "Immunohistochemical study of p53 expression in microwave-fixed paraffin sections of colorectal carcinomas and adenoma" Am. J. Clin. Pathol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuzawa, A. (Katagiri, T.): "A new allele of lpr locus, lpr^<cg>, that complements the gld gene in induction of lymphadenopathy in the mouse" J. Exp. Med.171. 519-531 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada, H. (Taniguchi, T.): "Absence of the type I IFN system in EC cells : Transcriptional activator (IRF-1) and repressor(IRF-2) genes are developmentally regulated" Cell. 63. 303-312 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-08-12  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi