1989 Fiscal Year Final Research Report Summary
Local activation of antitumor drugs in the body by ultrasound.
| Project/Area Number |
63044133
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Toho University |
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Principal Investigator |
UMEMURA Koshiro Toho University, Sch. Pharmaceutical Sci., Professor, 薬学部, 教授 (60147577)
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| Co-Investigator(Kenkyū-buntansha) |
DUNN Floyd University of Illinois, Dept. Electrical Engnr., Professor, Dept. of Ellectric, Professor
UMEMURA Shin-ichiro Hitachi Ltd., Central Research Laboratory, Head Researcher, 中央研究所, 主任研究員
YUMITA Nagahiko Toho University, Sch. Pharmaceutical Sci., Research Associate, 薬学部, 助手 (40191481)
NISHIGAKI Ryuichiro Toho University, Sch. Pharmaceutical Sci., Associate Professor, 薬学部, 助教授 (30111553)
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| Project Period (FY) |
1989
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| Keywords | Ultrasound / Hematoporphyrin / Cancer / Tumor / Cavitation / Active oxygen / Singlet oxygen / Electron spin resonance |
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| Research Abstract |
1. The antitumor effect of ultrasound (US) and the enhancement of it by hematoporphyrin (Hp), protoporphyrin, pheophorbide, adriamycin (ADM) and FAD104 were observed using cell suspensions of AH130 and sarcoma 180.2. Histidine, a singlet oxygen scavenger, inhibited the antitumor effect of US with or without Hp or ADM, while superoxide dismutase and mannitol did not. 3. In ESR study, the generation of singlet oxygen by US was shown using 4-oxo-TEMPO. Hp or ADM with US increased ESR signals. 4. Sonoluminescence spectrum was observed when a saline solution was irradiated. It was not affected by active oxygen scavengers, indicating it is caused by the high temperature generated by cavitation. 5. In vivo animal experiments, US irradiation to AH130 of rats inhibited the growth of tumor and prolonged the life of host rats. Hp administered to host rats increased the antitumor effect of US. ADM and FAD104 also increased the US effect on sarcoma 180 and colon 26 of mice. 6. A phased array US transducer that can focus US spatially was tested to irradiate the rat liver in vivo. A histological damage was observed only at the focus of US, but not at the surrounding region.
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Research Products
(6 results)
