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1991 Fiscal Year Final Research Report Summary

Studies on the determination of etiology of dementia and development of new diagnostic methods, therapies and drugs.

Research Project

Project/Area Number 63440035
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTokyo Women's Medical University

Principal Investigator

MARUYAMA Shoichi  Neurological Institute Tokyo Women's Medical College Professor, 医学部, 教授 (60075158)

Co-Investigator(Kenkyū-buntansha) SASAKI Shoichi  Neurological Institute Tokyo Women's Medical College Assistant, 医学部, 助手 (40119962)
OSAWA Mikio  Neurological Institute Tokyo Women's Medical College Instructor, 医学部, 講師 (60101812)
UCHIYAMA Shinichiro  Neurological Institute Tokyo Women's Medical College Instructor, 医学部, 講師 (50119905)
MURAKAMI Hirohiko  Neurological Institute Tokyo Women's Medical College Instructor, 医学部, 講師 (30120067)
KOBAYASHI Isturo  Neurological Institute Tokyo Women's Medical College Assistant professor, 医学部, 助教授 (50090527)
Project Period (FY) 1988 – 1990
KeywordsAlzheimer disease / multi-imfarct dementia / vasopressin / P300 / VEP / tau-protein / beta-amyloid protein / platelet aggregation
Research Abstract

Three-year Study Results
We conducted various studies to determine the etiology of dementia and develop new diagnostic methods, therapies and drug over the 3-year period between 1988 and 1990 and obtained the results (most of which are new findings) summarized below.
1. Neurophysiological studies ; Latency for event-related potential (P300), long latency reflex (LLR), auditory brain stem response (ABR) and visual evoked potential (VEP) increased significantly in patients with various neurological disorders in which dementia or impaired cerebral function is suspected, including not only Alzheimer-type dementia (ATD) and multi-infarct-dementia (MID) but also motorneuron diseases, dialysis encephalopathy and subacute combined degeneration of the spinal cord.
2. Neuropsychological studies. : In patients with the above-mentioned diseases, Hasegawa's Dementia Scale, Mini-Mental State and WAIS showed significant correlation with P300 and other neurophysiological tests.
3. Neurobiochemical studies … More : Vasopressin (AVP) and thyrotropin releasing hormone (TRH) showed positive correlation with age in the MID and control groups and negative correlation in the ATD group, suggesting the presence of differences in the biochemical role of neuro-peptides in the ATD group and other groups. Elucidation of these differences has come into the spotlight as a major study objective.
4. Studies related to blood coagulation : Platelet aggregation, beta-TG, PF4, prostanoids and molecular markers showed abnormalities in the MID group.
5. Neuropathological studies : It was shown that cell density in Meynert's nuclei which project cholinergic neurons is decreased in patients with Pick disease with dementia and that micromorphological and immunohistological findings of senile plaques, amyloid beta-protein and tau-protein are related to dementia in the brain of progressive supranuclear palsy.
6. Pharmacotherapy and prevention of dementia : VAP administration resulted in significant increases in VAP and TRH concentrations in the cerebrospinal fluid in dementia patients who showed improvement. It was also confirmed that reversal of blood coagulation abnormality using drugs and maintenance of appropriate blood pressure are very important in preventing MIS manifestation. Less

  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] Mikio Osawa, et. al.: "Cognitive function in chronic hemodialysis patients as evaluated by P300" Tosekikaishi. 21. 757-761 (1988)

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  • [Publications] Mikio Osawa, et. al.: "Cognitive function in cerebral palsy -Evaluation by event-related potential (P300) -" Rinsho noha. 31. 439-442 (1989)

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  • [Publications] Mikio Osawa, et. al.: "Cognitive function in Wilson's disease-efects of trien therapy on P300 -" Rinsho noha. 31. 202-204 (1989)

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  • [Publications] Mikio Osawa, et. al.: "P300 in various neurological disorders" Rinsho noha. 31. 103-109 (1989)

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  • [Publications] Yuko Shimizu, et. al.: "A case of Subacut Combined Degeneration of the Spinal Cord : Evaluation of the Cognitive Function by Event-related Potential (P300)" Tokyo Joshi Ikadai Zasshi. 60. 88-93 (1990)

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  • [Publications] Harunobu Nakayama, et. al.: "Aging effect on frontal lobe function-evaluation by the new modified wisconsin card sorting test" Brain and Nerve. 42. 765-771 (1990)

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  • [Publications] Keiko Ota, st. al.: "A study of blink reflex in vascular disorders in the brain stem-comparison with MRI findings" Rinsho noha. 31. 794-798 (1989)

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  • [Publications] Hidekazu Kamei: "Correlation of auditory brain stem response and the MRI measurements in Neuro-degenerative disorders" Tokyo Joshi Ikadai Zasshi. 59. 645-659 (1989)

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  • [Publications] Riuko Endo: "A study of the Clinical and the Neuroradiological findings in Multi-infarct dementia and Alzheimer type dementia" Tokyo Joshi Ikadai Zasshi. 59. 693-704 (1989)

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  • [Publications] Mikio Osawa, et. al.: "Midbrain Asterixis" Tokyo Joshi Ikadai Zasshi. 57. 813-819 (1987)

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  • [Publications] Koichi Shibara: "A study of pattern reversal visual evoked potential in neurological disorders" Tokyo Joshi Ikadai Zasshi. 59. 672-682 (1989)

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  • [Publications] Mikio Osawa: "Clinical application of surface elecrtromyography" Tokyo Joshi Ikadai Zasshi. 59. 499-513 (1989)

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  • [Publications] Mikio Osawa, et. al.: "Negative myoclonus" Rinsho noha. 32. 582-587 (1990)

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  • [Publications] Satoshi Komatsuzaki, et. al.: "Clinical study in periodic abnormal electroencephalogram" Rinshonoha. 33. 413-417 (1991)

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  • [Publications] Satoshi Komatsuzaki: "Evaluation of long latency reflex in cerebral palsy" Tokyo Joshi Ikadai Zasshi. 59. 167-176 (1989)

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  • [Publications] Koichi Shibata, et. al.: "A study of pattern reversal visual evoked potential and electroretinogram in cerebral palsy" Rinsho noha. 32. 745-749 (1990)

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  • [Publications] Hidekazu Kamei, et. al.: "A study of middle latency response in patients will cerebral palsy" Rinsho noha. 32. 668-672 (1990)

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  • [Publications] Mikio Osawa, et. al.: "L-dopa induced asterixis- A Clinical and Physiological study -" Tokyo Joshi Ikadai Zasshi. 57. 296-302 (1987)

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  • [Publications] Mikio Osawa, et. al.: "Effect of Indeloxazine Hydrochloride (Elen^R) on Event-related Potential (P300) in patients with Parkinson disease and parkinsonism" Geriat. Med.28. 1875-1883 (1990)

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  • [Publications] Reiko Sone, et. al.: "Effects of Tiapride on Involuntary Movements in Chorea-acanthocytosis" Neurological Therapeutics. 6. 447-451 (1989)

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  • [Publications] Mikio Osawa, et. al.: "Effects Idebenone (Avan^R) on Event-Related Potential (P300) in Patients with Cerebrovascular Disease" Jpn Pharmacol Ther. 18. 1307-1318 (1990)

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  • [Publications] Kyoko Okada, et. al.: "Electrophysiological study in familial tremor - special reference to the differences between patients with and without epilepsy -" Rinsho noha. 32. 352-356 (1991)

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  • [Publications] Michiko Ikezawa, et. al.: "Effect of Acetazolamide in a Patient with Sleep Apnea Syndrome" Tokyo Joshi Ikadai Zasshi. 59. 789-792 (1989)

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  • [Publications] Mikoo Osawa, et. al.: "Central motor conduction time in HTLV-I associated myelopathy (HAM) -Evaluation by transcutaneous stimulation of the cerebral motor cortex and spinal cord." Rinsho noha. 30. 473-475 (1988)

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  • [Publications] Yoshiko Furiya, et. al.: "A case of Cranial Polyneuritis Presenting Facial Diplegia" Tokyo Joshi Ikadai Zasshi. 59. 777-782 (1989)

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  • [Publications] Mutsumi Iijima, et. al.: "Nocturnal myoclonus in HTLV-I associated myelopathy (HAM) - study by polysomnograph-" Rinsho noha. 33. 190-194 (1991)

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  • [Publications] Keiko Ota, et. al.: "A case of gerumanium intoxication with no early component of of blink reflex" Rinsho noha. 33. 62-65 (1991)

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  • [Publications] Kenji Yamamoto, et. al.: "Two Brothers of a Family with Heredofamilial Tremor Associated with Epilepsy : Neurophysiological Study" Tokyo Joshi Ikadai Zasshi. 59. 585-591 (1989)

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  • [Publications] Kyoko Okada, et. al.: "Electrophysiological study in HTLV-I associated myelopathy (HAM)" Rinsho noha. 32. 803-808 (1990)

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  • [Publications] Keiko Ota, et. al.: "Electrophysiological studies in myotonic dystrophy" Rinsho noha. 32. 536-540 (1990)

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  • [Publications] Koichi Shibata, et. al.: "Hemiplegia as an initial symptom of subacute sclerosing panencephalitis (SSPE)" Neurol. Med.33. 257-259 (1990)

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  • [Publications] Masatomi Honda, et. al.: "A Rrial of Diet, Plasma Exchange and Methylprednisolone Pulse Therapy for a Patient with Adrenoleukodystrophy" Neurological. Therapeutics. 7. 35-41 (1990)

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  • [Publications] Hidekazu Kamei, et. al.: "Myasthenic state associated with hypothyroidism" Neurol. Med.31. 522-524 (1989)

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  • [Publications] Reiko Sone, st. al.: "Diagnostic Value of MRI in Cerebrovascular Disease" Tokyo Joshi Ikadai Zasshi. 59. 579-584 (1989)

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  • [Publications] Shinichiro Uchiyama, et. al.: "Role of thromboxane A_2 in thrombosis and hemostasis : Antiplatelet and antithrombotic effects of thromboxane A_2 receptor antagonist" Blood & Vessel. 18. 155-157 (1987)

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  • [Publications] Hirohiko Murakami, et. al.: "Production of 12-Hydroxyeicosatetraenoic Acid (12-HETE) from Platelets Challenged by Arachidonate in Ischemic Attack" Tokyo Joshi Ikadai Zasshi. 59. 560-563 (1989)

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  • [Publications] Itsuro Kobayashi, et. al.: "Measurement of ATP Release from Platelet in Acute Cerebral Thrombosis" Tokyo Joshi Ikadai Zasshi. 59. 548-550 (1989)

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  • [Publications] Takashi Nagayama, et. al.: "An Attempt of the Measurement of Erythrocyte Deformability by Viscometry" Tokyo Joshi Ikadai Zasshi. 59. 564-568 (1989)

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  • [Publications] Megumi Takeuchi, et. al.: "Serum Lipids and Platelet Functions in Ischemic Cerebrovascular Diseases" Tokyo Joshi Ikadai Zasshi. 59. 177-183 (1989)

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  • [Publications] Masako Mochizuki, et. al.: "Alterations of Hrmostatic Markers in Cardioembolic Stroke" Kessen shiktsushi. 1. 527-532 (1990)

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  • [Publications] Shinichiro Uchiyama, et. al.: "Effects of Dilazep on Erythrocyte Membrane Fragility in Cerebral Thrombosis" The Clinical Report. 22. 6429-6432 (1988)

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  • [Publications] Shinichiro Uchiyama, et. al.: "Antiplatelet effects of combination therapy with low doses of aspirin and ticlopidine in cerebral ischemia" Blood & Vessel. 19. 390-393 (1988)

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  • [Publications] Shinichiro Uchiyama, et. al.: "Antiplatelet effects of combination therapy with low-dose aspirin and ticlopidine in cerebral ischemia" Clin. Neurol.29. 579-583 (1989)

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  • [Publications] Shinichiro Uchiyama, et. al.: "Combination Therapy with Low-Dose Aspirin and Ticlopidine in Cerebral Ischemia" Stroke. 20. 1643-1647 (1989)

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  • [Publications] Pao-Yu Wang, et. al.: "The Effects of CV-4151 on Thrompbxane A_<>-Dependent Platelet Aggregation in Patients with Ischemic Stroke" Shinyaku to Rinsho. 39. 2063-2071 (1990)

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  • [Publications] Yukiko TsuTsumi, et. al.: "A case of cerebral infarction presenting periodic lateralized epileptiform discharges" Rinshonoha. 33. 292-294 (1991)

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  • [Publications] Yasuhiro Maeda, et. al.: "A case of Pseudoxanthoma Elasticum Showing Various Heteroptics due to Infarction of Right Parieto-Occipital Lobe" Brain and Nerve. 39. 251-256 (1987)

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  • [Publications] Miyuki Kikuchi, et. al.: "A Case of Chronic Cavernous Sinus Thrombosis" Tokyo Joshi Ikadai Zasshi. 59. 793-797 (1989)

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  • [Publications] Shoichi Sasaki, et. al.: "Loss of neurons in the nucleus basalis of Meynert in Pick disease" Clin. Neurol.25. 812-817 (1985)

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  • [Publications] Shoichi Sasaki, et. al.: "Ultrastructure of swollen proximal axons of anterior horn neurons in motor neuron disease" Neuro. Sci.97. 233-240 (1990)

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  • [Publications] Shoichi Sasaki, et. al.: "Observation of the Proximal Protions of Axons of Anterior-Horn Cells in the Human Spinal Cord" Act. Anat.139. 26-30 (1990)

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  • [Publications] Shoichi Sasaki, et. al.: "Sporadic motor neuron disease with Lewy body-like hyaline inclusions" Acta Neuropathol.78. 555-560 (1989)

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  • [Publications] Shoichi Sasaki, et. al.: "Swelling of Proximal Axons in a Case of Motor Neuron Disease" Ann. Neurol.25. 520-522 (1989)

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  • [Publications] Shoichi Sasaki, et. al.: "Swelling of neuronal processes in motor neuron disease" Neurology. 38. 1114-1118 (1988)

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  • [Publications] Shoichi Sasaki, et. al.: "An autopsy case of human T lymphotropic virus type I-associated myelopathy (HAM) with a duration of 28 years" Acta Neuropathol.81. 219-222 (1990)

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  • [Publications] Ai Kakaji, et. al.: "Malignant lymphoma presenting with progressive dementia caused by multiple cerebral tumor embolism" Neurol. Med.28. 415-418 (1988)

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Published: 1993-03-16  

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