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1991 Fiscal Year Final Research Report Summary

Study on multi-phase artificial jaw and dental implant materials with soft-tissue affinity and biofunctionality

Research Project

Project/Area Number 63440079
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionKanagawa Dental Collage (1989-1991)
Iwaki Meisei University (1988)

Principal Investigator

SHIMURA Kaizo  Kanagawa Dental Collage・Dentistry, Prof, 歯学部, 教授 (20084725)

Co-Investigator(Kenkyū-buntansha) OHTSUKA Tohru  Kanagawa Dental Collage・Dentistry, assistant, 歯学部, 助手 (20168991)
KOBAYASHI Masaru  Kanagawa Dental Collage・Dentistry, assistant, 歯学部, 助手 (00162024)
KIRIGAKUBO Mitsuhiro  Kanagawa Dental Collage・Dentistry, lecturer, 歯学部, 講師 (30186358)
KINOSHITA Yukihiko  Kanagawa Dental Collage・Dentistry, adjunct Prof, 歯学部, 助教授 (70084770)
MASUHARA Eiichi  Tokyo Medical and Dental University・Dentistry, Prof emeritus, 歯学部, 名誉教授 (00013772)
Project Period (FY) 1988 – 1991
Keywordssoft-tissue affinity / biofunctionality / multi-phase biomedical material / artificial jaw bone / dental implant / collagen-immobilization / finite element method / shock-absorbing structure
Research Abstract

In order to improve the soft-tissue affinity of artificial materials and to obtain a tight attachment of surrounding tissue such as gingiva, we tried to immobilize collagen onto the surface of materials. Collagen-immobilization was performed by a plasma-polymerizing apparatus, which had been purchased with grant-in-aid for scientific research. First, we set up the proper conditions for pretreatment and plasma polymerization. By means of this method, collagen wad connected with materials by covalent bonding, and it became possible to immobilize collagen firmly and with long-term stability onto the surface of materials even in a moist environment such as a living body. Then, collagenimmobilized porous polyethylene pieces were implanted subcutaneously in the backs of rats, and subsequent histological reactions were examined.
As a result. connective tissue grew into the pores of the porous polyethylene pieces soon after implantation, and the rate of tissue ingrowth was substantially improve … More d. The surrounding tissue attached itself to the material, and at material-tissue interface living-body-originated collagen fibers were observed to be firmly attached to the surface of the material. This condition continued for more than one year after implantation. Therefore this method proved to be very effective in improving the soft-tissue affinity of artificial materials, suggesting possibility that this method could be clinically applied.
At the same time, to improve biomechanical compatibility of dental implants and artificial jaw bones by providing biofunctionality such as deformity and shock-absorbablity such as that possessed by natural teeth and bony tissue. we analyzed the mechanical response of natural teeth and bones under functional stress using a finite element analysis system, which was purchased with grant-in-aid for scientific research.
The result indicated that the periodontal membrane plays a role in dispersing stress around the bony sockets of teeth under a static load and absorbing shock under a dynamic load. Moreover, these results suggested that dental implants should be designed with a shock-absorbing structure inside the root, which could provide physical displacement and shock-absorbability like natural teeth in order to compensate for the function of the periodontal membrane. Following these results, we developed a new dental implant. which has a shock-absorbing structure inside the root, and we examined its actual displacement and shock-absorbability.
Our findings indicated that the new dental implant had a larger displacement as well as a remarkably higher shock-absorbability Therefore, we expect that this implant will be very effective in clinical use Less

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Kinoshita Y,et al.: "Soft Tissue Reaction to Collagen-immobilized Porous Polyethylene-Subcutaneous Implantation in Rat for 20 weeks." Biomaterials. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kioshita Y,et al.: "Reduction in tumor formation on Porous Polyethylene by Collagen immobilization" Biomaterials. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 桐ヶ久保 光弘,他: "インプラントの経過不良について" 歯科ジャ-ナル. 36. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinoshita, Yukihiko., et al.: "Soft Tissue Raction to Collagen-immobilized Porous Polyethylen - Subcutaneous Implantation in Tats for 20 Weeks -" Biomaterials. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinoshita, Yukihiko., et al.: "Raction in Tumor formation on Porous Polyethylene by Collagen immobilization" Biomaterials. (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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