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1990 Fiscal Year Final Research Report Summary

Chemical Studies on Bioactive Substances Against Insects from Marine Organisms

Research Project

Project/Area Number 63470022
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 天然物有機化学
Research InstitutionKochi University

Principal Investigator

OCHI Masamitsu  Kochi Univ. Faculty of Sci., Prof., 理学部, 教授 (40036562)

Co-Investigator(Kenkyū-buntansha) IWASAKI Nozomu  Kochi Univ. Usa Mar. Biol. Inst., Assitant, 海洋生物教育研究センター, 助手 (20193724)
OHNO Masao  Kochi Univ. Usa Mar. Biol. Inst., Prof., 海洋生物教育研究センター, 教授 (10036543)
KOTSUKI Hiyoshizo  Kochi Univ. Faculty of sci., Assoc. Prof., 理学部, 助教授 (80093954)
Project Period (FY) 1988 – 1990
KeywordsMarine Products / Octocorals / Silkworm / Brine-Shrimp / Drupella fragum B. / Chemical Defense Mechanisms
Research Abstract

1. Collection and Screening
We collected fifty-one species of marine algae and seventy-nine species of sessile invertebrates from the coastal waters of southwestern Shikoku, and subjected the crude extracts obtained from them to screening for insect growth inhibitory activity against silkworm larvae and for lethality to brine-shrimp larvae. Of these extracts examined, those from twenty-seven species belonging to the Subclass Octocorallia exhibited significant activities against the test animals.
2. Isolation and Structural Determination
We investigated the biologically active constituents of five octocorals, Litophyton sp., Calicogorgia sp., Muricella sp., Ellisella SP., and Acalycigogia sp., to isolate thirty-three diterpenoids, two branched-chain lipids, three sphinganine derivatives, and five Secosterols. Their structures were established on the basis of spectroscopic and chemical evidence.
3. Biological Activities of Isolated Compounds
We evaluated biological activities of above compounds against silkworm and brine-shrimp larvae. Most of diterpenoids exhibited significant activities in both assays. Secosterols showed only lethality to brine-shrimp, while branched-chain lipids and sphinganine derivatives were all inactive in both assays. On the other hand, in order to elucidate the ecological role of these compounds in marine habitats, we also examined repelling and lethal activities against the muricid gastropod, Drupella fragum B., which has caused an environmental problem in the coastal waters of the Southwest of Japan by population explosions with widespread destruction of scleratinian corals. Many of diterpenoids, branched-chain lipids, and sphinganine derivatives were found to serve as defensive allomones.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Masamitsu Ochi: "Litophynin C,a New Insect Growth Inhibitory DiterPenoid from a Soft CoralLitophyton sp." Chemistry Letters. 1661-1662 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masimitsu Ochi: "Litophytolides A and B,Two New Lipids of a Soft Coral Litophyton sp." Heterocycles. 29. 39-41 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Litophynin D and E,Two New Diterpenoids from a Soft Coral Litophyton sp." Chemistry Letters. 2183-2186 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Calicophirins A and B,Two New Insect Growth Inhibitory Diterpenoids from a Gorgonian Coral Calicogorgia sp." Heterocycles. 32. 19-21 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Calicoferols A and B, Two Novel Secosterols Possessing BrineーShrimp Lethality from the Gorgonian Calicogorgia sp." Chemistry Letters. 427-430 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Litophynins F,G,and H,Three New DiterPenoids from a Soft Coral Litophyton sp." Heterocycles. 32. 29-32 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Ochi :"Litophynin C, a New Insect Growth Inhibitory Diterpenoid from a Soft Coral Litophyton sp." Chim. Lett.1661-1662 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Ochi: "Litophytolides A and B, Two New Lipids of a Soft Coral Litophyton sp." Heterocycles. 39-41 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Ochi: "Litophynin D and E, Two New Diterpenoids from a Soft Coral Litophyton sp." Chem. Lett.,. 2183-2186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Ochi: "Calicophirins A and B, Two New Insect Growth Inhibitory Diterpenoids from a Gorgonian Coral Calicogorgia sp." Heterocycles. 32. 19-21 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Ochi: "Calicoferols A and B, Two Novel Secosterols Possessing Brine-Shrimp Lethality from the Gorgonian Calicogorgia sp." Chem. Lett.427-430 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Ochi: "Litophynins F, G, and H, Three New Diterpenoids from a Soft Coral Litophyton sp." Heterocycles. 32. 29-32 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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