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1990 Fiscal Year Final Research Report Summary

Pathogenesis of Hereditary Hepatitis in LEC Rats

Research Project

Project/Area Number 63480145
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionSapporo Medical University

Principal Investigator

MORI Michio  Sapporo Medical College, Dept. Pathol., Professor, 医学部, 教授 (00045288)

Co-Investigator(Kenkyū-buntansha) HATTORI Atsuo  Sapporo Medical College, Dept. Pathol., Instructor, 医学部, 助手 (90208538)
ENOMOTO Katsuhiko  Sapporo Medical College, Dept. Pathol., Associate Professor, 医学部, 助教授 (20151988)
Project Period (FY) 1988 – 1990
KeywordsHereditary hepatitis / Liver cell injury / Fulminant hepatitis / Chronic hepatitis / Liver cancer / Animal model / 肝癌発生機構
Research Abstract

The LEC strain of rats, which spontaneously develop acute hepatitis associated with jaundice, chronic hepatitis and finally hepatocellular carcinomas, was found and established recently at the Center for Experimental Plants and Animals, Hokkaido University, Sapporo.
We have extensively studied the pathogenesis of spontaneous hepatitis in the LEC rat and found that the hepatitis is controlled by a single autosomal recessive gene. No infectious agents were detected. Abnormally high ploid nuclei were found in the hepatocyte of the LEC rat, but no direct relation between such an abnormality in the ploidy and the development of hepatitis was found. Experimental studies have shown that the LEC rat is highly sensitive to the hepatotoxic effect of D-galactosamine. Biochemical studies revealed that the S-adenosylmethionine synthetase activity in the liver of LEC rat is low at birth and decreased to a half level on the time of the onset of hepatitis, suggesting that the decrease in this enzyme have a key role for the development of spontaneous hepatitis and high sensitivity of the LEC rat to D-galactosamine hepatotoxicity.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Fujimoto,Y.,Oyamada,M.,Mori,M.et al.: "Accumultion of abnormally high ploid nuclei in the liver of LEC rats developing spontaneous hepatitis." Jpn.J.Cancer Res.80. 45-50 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto,Y.,Takahashi,H.,Mori,M. et al.: "Hereditary hepatitis in LEC rats:Accumulation of abnormally high ploid nuclei." Cancer Detect.Prevent.14. 235-237 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu,K.,Tsukada,K.,Mori,M.et al.: "Decreased activities of Sーadenosylmethioine synthetase isozymes in hereditary hepatitis in LongーEvans rats." Life Sci.46. 1837-1842 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi,H.,Enomoto,K.,Mori,M. et al.: "High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine." Cancer Let.,. 51. 247-250 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawaki,M.,Enomoto,K.,Mori,M.et al: "Phenotype of preneoplastic and neplastic liver lesions during spontaneous liver carcinogenesis of LEC rats" Carcinogenesis,. 11. 1857-1861 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Enomoto,K.,Takahashi,H.and Mori,M.: "A new rat model for the study of hepatocarcinognensis." J.Gastroenterol.Hepatol.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori,M.,Yoshida,M.C.,Takeichi,N.and Taniguchi,N.: "The LEC Rat:A New Model for Hepatitis and Liver Cancer." SpringerーVerlag, 256 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto, Y., Oyamada, M., Mori, M. et al.: "Accumulation of abnormally high ploid nuclei in the liver of LEC rats developing spontaneous hepatitis." Jpn. J. Cancer Res.80. 45-50 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto, Y., Takahashi, H., Mori. M. et al.: "Hereditary hepatitis in LEC rats : Accumulation of abnormally high ploid nuclei." Cancer Detect. Prevent.14. 235-237 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu, K., Tsukada, K., Mori, M. et al.: "Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats." Life Sci.46. 1837-1842 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, H., Enomoto, K., Mori, M. et al.: "High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine." Cancer Let.51. 247-250 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawaki, M., Enomoto, K., Mori, M. et al: "Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats" Carcinogenesis,. 11. 1857-1861 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Enomoto, K., Takahashi, H. and Mori, M.: "A new rat model for the study of hepatocarcinognensis." J. Gastroenterol. Hepatol.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori, M., Yoshida, M. C., Takeichi, N. and Taniguchi, N.: Springer-Verlag,. The LEC Rat : A New Model for Hepatitis and Liver Cancer., 1991.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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