• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1989 Fiscal Year Final Research Report Summary

Virological and immunological study on non-A, non-B hepatitis

Research Project

Project/Area Number 63480200
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionShinshu University

Principal Investigator

FURUTA Seiichi  Shinshu University, 2nd Department, Professor, 医学部第二内科学教室, 教授 (20020852)

Co-Investigator(Kenkyū-buntansha) GIBO Yukio  ditto ditto, 医学部第二内科学教室, 講師 (40161616)
SODEYAMA Takeshi  ditto Assistant Professor, 医学部第二内科学教室, 講師 (00163139)
KIYOSAWA Kendo  ditto Associate Professor, 医学部第二内科学教室, 助教授 (30020829)
Project Period (FY) 1988 – 1989
KeywordsNon-A, non-B hepatitis / Type C hepatitis / Liver cirrhosis / Hepatocellular carcinoma / Interferon therapy / インタ-フェロン療法
Research Abstract

We have tried to detect the virus(es) in the hepatocytes arid lymphocytes of primary culture after being obtained from patients with non-A,non-B hepatitis. However, until now we could not find any responsible agent by this method. In 1989, Choo et al and Kue et al in Chiron Co. research group diicceeded to isolate the gene product of hepatitis C virus (HCV) and established an assay system for circulating antibody to HCV. Using the ELISA test kit provided by Ortho Diagnostic System Co., iwe tested anti-HCV antibody in sera of patients with acute and chronic liver diseases of non-A,non-B type. Anti-HCV antibody vas positive in 44 % of acute sporadic non-A,non-B hepatitis, in 62 % of posttransfusion non-A,non-B hepatitis, in 76 % of chronic hepatitis of non-A,non-B type, in 64 %"of liver cirrhosis and 70 % of hepatocellular carcinoma of non-A,non-B type respectively: To the contrary, in type B hepatitis and cirrhosis, this antibody vas detected only in less than 5 %.
Among the patients with non-A,non-B acute hepatitis, anti-HCV positive cases had a significantly higher tendency to chronicity as compared with anti-HCV negative cases. All 15 cases of chronic hepatitis and cirrhosis of,.posttransfusion etiology who developed finally hepatocellular carcinoma were positive for anti-HCV, indicating that there is a intimate relationship between persistent HCV infection and development of hepatocellular carcinoma.
Regarding to the response to interferon administration in non-A,non-B chronic hepatitis, serum beta 2 microglobulin level was much less elevated and intrahepatic expression of HLA class 1 antigen was much weaker as compared with those in chronic hepatitis type B. However, intralobular infiltrating lymphocytes decreased much more significantly in grade after interferon administration as compared to that in chronic hepatitis of type B, suggesting that there are differences of therapeutic responses to interferon between non-A,non-B hepatitis and type B hepatitis.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 古田精市: "散発性C型肝炎-臨床像とHCVの感染性" 医学のあゆみ. 151. 761-765 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清沢研道,小池ゆり子: "HCV抗体陽性肝硬変の予後-とくに肝細胞癌への移行" 医学のあゆみ. 151. 826-829 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kiyosawa,T.Sodeyama,S.Furuta 他6名: "Treatment of chronic non-A,non-B hepatitis with human interferon β: a preliminary study" Antiviral Research. 12. 151-162 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古田精市,清沢研道,他3名: "慢性肝炎,肝硬変とC型肝炎" 肝胆膵. 20. 35-40 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古田精市,清沢研道,神山健,他2名: "非A非B型肝炎研究の進歩とC型肝炎ウイルス抗体の臨床的意義" 日本臨牀. 48. 39-46 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kendo Kiyosawa,Takeshi Sodeyama,Seiichi Furuta,他4名: "Viral Hepatitis and Lirer Disease "Tretment of chronic non-A,non-B hepatitis with β-interferon"" Ed.A.J.Zuckerman(Alan R.Liss Inc.New York), pp895-897 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furuta Seiichi: "Sporadic acute type C hepatitis Clinical features and infectivity of HCV" Igakunoayumi, 151: 761-765, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kiyosawa Kendo Koike Yuriko: "Prognosis of anti-HCV positive liver cirrhosis" Igakunoayumi 151: 826-829, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kiyosawa Kendo Sodeyama Takeshi Furuta Seiichi et al.: "Treatment of chronic non-A, non-B hepatitis with human interferon beta : a preliminary study" Antiviral Research 12: 151-162, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuta Seiichi Kiyosawa Kendo et al.: "Hepatitis C vrrus in chronic hepatitis and liver cirrhosis" Kan-Tan-Sui, 20: 34-40, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuta Seiichi Kiyosawa Kendo et al: "Progress in non-A, non-B hepatitis research and clinical significance of anti-HCV" Nihonrinsho : 48: 39-46, 1990.

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi