1990 Fiscal Year Final Research Report Summary
Studies on the Pathogenesis of Immune Disorders by the Analysis of the Differentiation and Regulation of the Lmyphocytes.
| Project/Area Number |
63480234
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YATA Junichi Tokyo Medical and Dental University Professor Faculty of Medicine, 医学部, 教授 (60057502)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Primary immunodeficiency / T cell differentiation / Regulation by NK cells / sigmadelta T cells / Allergen-specific B cells / Hashimot's thyroiditis / Anti-thyroglobulin antibody |
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| Research Abstract |
The lymphocytes from immune disorders were analyzed for their differentiation and the regulatin of their functions in order to disclose the pathogenesis. T cells can be divided into alphabeta type and sigmadelta type according to the peptides constituting the antigen receptor. The later T cells are less dependent on the thymus and seem to be more primitive. Sigmadelta T cells were increased in some of the immunodeficiency patients with T cell deficiency indicating compensations of ordinary T cells. However, part of the cytotoxic function of these sigmadelta T cells was impaired and their differentiation was suggested to be not complete. Bone marrow cells and later irradiated thymus were transplanted to a patient with T cell defect probab lly due to impaired development of lymphoid stem cells. NK cells was generated but T cells developed only after thymus transplantation. NK cells seemedo down-regulate the generation of granulocytes and T cells did that of NK cells, which suggested the
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presence of mutual regulation among granulocytes, NK cells and T cells. Thus appeared sigmadelta T cells responded well to interleukin (IL) -2 but alphadelta T cells did not. Allogeneic irradiated thymus might not be sufficient for the full differentiation of alphadelta T cells. It was suggested by a case with normal B cells and hypogammaglobulinemia that impaired differentiation of CD4^+T cells from CD45RA^+ to CD45RO^+ causes defective helper function. The number of ovalbumin (OVA) specific B cells was observed to increase gradually according to age and was more prominent in OVA-allergic patients. The increase of OVA-specific B cells preceded to the appearance of serum anti-OVA antibody. Enumulation of allergenspecific B cells may be valuable to predict food allevgy. In vitro study of antithyroglobulin antibody production from Hashimoto's thyroiditis revealed that B cells were fully activated in some patients and they were inactive for moment but showed potentiality to produce the antibody in other patients. Less
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[Publications] Nonoyma,S.,Minaguchi,J.,Takase,K.,Okawa,H.,Yata,J.,Ohira,M.,Nishihira,H.,Onozawa,Y.,Sakamaki,H.,Imai,: "Lymphocytes after autologous allogeneic bone marrow transplantation." Acta Paediatrica Japonica. 31. 469-475 (1989)
Description
「研究成果報告書概要(和文)」より
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[Publications] Morio,T.,Takase,K.,Okawa,H.Oguchi,M.,Kanbara,M.,Hiruma,F.,Yoshino,K.,Kanko,T.Asamura,S.^<・・・> and Yata,J.: "The increase of nonーMHCーrestricted cytotoxic cells(γδーTCR bearing T cells or NK cells)and the abnormal differentiation of B cells in WiskottーAldrich syndrome." Clinical Immunology and Immunopathology. 52. 279-290 (1989)
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「研究成果報告書概要(和文)」より
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[Publications] Nonouama, S., Minaguchi, J., Takase, K., Okawa, H., Yata, J., Ohira, M., Nishihira, H., Onozawa, Y., Sakamaki, H. and Imai, K. :"Lymphocytes after autologous and allogeneic bone marrow transplantation." Acta Paediatr. Jpn.31(2). 469 (1989)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Morio, T., Takase, K., Okawa, H., Oguchi, M., Kanbara, M., Hiruma, F., Yoshino, K., Kaneko, T., Asamura, S., Inoue, T., Tsuji, Y., Tasaka, H., Kakei, I., Miyata, K. and Yata, J. :"The increase of non-MHC-restricted cytotoxic cells (signd/delta-TCR bearing T cells or NK cells) and the abnormal differentiation of B cells in Wiskott-Aldrich syndrome." Clin. Immunol. Immunopathol.52(2) :. 279, (1989)
Description
「研究成果報告書概要(欧文)」より
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