Development of Analytical Method of Hemodynamics in Liver Using Radionuclide Tracers

1990 Fiscal Year Final Research Report Summary

• Project/Area Number: 63480253
• Research Category: Grant-in-Aid for General Scientific Research (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Ehime University
• Principal Investigator: HAMAMOTO Ken Ehime University, School of Medicine, Radiology, Professor, 医学部, 教授 (50026895)
• Co-Investigator(Kenkyū-buntansha): MOGAMI Hiroshi Ehime University, School of Medicine, Radiology, Instructor, 医学部・附属病院, 助手 (00157819) ; MURASE Kenya Ehime University, School of Medicine, Radiology, Instructor, 医学部, 助手 (50157773) ; TANADA Shuji Ehime University, School of Medicine, Radiology, Assist. Professor, 医学部・附属病院, 講師 (40116950) ; ITO Atsushi Ehime University, School of Medicine, Radiology, Assoc. Professor, 医学部・附属病院, 助教授 (20109002)
• Project Period (FY): 1988 – 1990
• Keywords: Hepatic blood flow / Portal blood flow / Xenon-133 washout / Transcatheter arterial embolization / Hepatocellular carcinoma / Liver cirrhosis / Balloon catheter / Expracorporeal measure

Research Abstract

The investigation was undertaken to measure regional potal blood flow of the liver. The measurement was performed by injecting Xenon 133 into proper hepatic artery through a ballooon catheter ans then occluding the proper hepatic artery with an inflated balloon. Data was collected using a gamma camera, and washout curves were generated. They were analyzed by the initial slope method and kety-Schmidt equation. The average regional potal blood flow were : 59.31 <plus-minus> 13.04 ml/100g per min, 58.71 <plus-minus> 14.14 ml/100g per min and 37.12 <plus-minus> 10.11 ml/100g per min in hospital controls, patients with chronic hepatitis and those with liver cirrhosis, respectively. In the patients with liver cirrhosis, the regional potal blood flow was significantly reduced (P 0.01). The reproducibility of this method was satisfactory. The measurement of regional potal blood flow will be useful to evaluate underlying liver injuries and determine indications of a transcatheter arterial embolization of the

Research Products

• [Publications] 安原 美文 他: "A measurment of regional portal blood flow with Xeー133 and baloon catheter in man" European J. Nuclear Medicine. 15. 346-350 (1989)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 宮内 総一郎 他: "Clinical Slghificance of measurement of hepatic blood flow using Xenonー133 and baloon Catheter in patients treatment for hepatocellular Carcinoma" European J.Nuclear Medicine. 16. (1991)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Y. Yasuhara, S. Miyauchi, and K. Hamamoto: "A measurement of regional portal blood flow with Xe-133 and balloon catheter in man" EurJ Nucl Med. 15. 346-350 (1989)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K. Hamamoto, Y. Yasuhara, A. Iio, S. Tanada, K. Murase: "Development of an analytical method of hemodynamics in liver using radionuclide tracers" Innervision. 11-13 (1989)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] S. Miyauchi, Y. Yasuhara, and Y. Ohta: "Clinical significance of the measurement of hepatic blood flow using Xenon 133 and balloon catheter in patients undergoing treatment for hepatocellular carcinoma" Eur J Nucl Med. (1991)
  • Description: 「研究成果報告書概要(欧文)」より