1989 Fiscal Year Final Research Report Summary
Experimental Study of the Influence of Intraperitoneal Thermochemotherapy on the Healing of Intestinal Anastomoses
| Project/Area Number |
63480305
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tottori University |
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Principal Investigator |
MAETA Michio Tottori University Assistant Professor, 医学部, 講師 (70032208)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAZOE Ryuichi Tottori University Assistant, 医学部, 助手 (40156394)
SHIMIZU Morio Tottori University Assistant Professor, 医学部附属病院, 講師 (40108808)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Peritoneal dissemination / Intestinal anastomosis / Continuous hyperthermic peritoneal perfusion / Wound healing / Intraabdominal thermochemotherapy |
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| Research Abstract |
When hyperthermia is applied in the peritoneal cavity after surgery, it is important to ask whether or not it interferes with the subsequent healing of intestinal anastomoses. To study this problem, rats with intestinal anastomoses were prepared and divided into 3 groups. In group A, local hyperthermia (44.0ﾟC x 30 min.) was applied to the intestinal loop that containes anastomoses using saline. in group B, local hyperthermia (44.0ﾟC x 30 min.) was applied using saline supplemented with Mitomycin C (MMC; 10 mg/L). In the control group, no thermal treatment was applied. In each groups, rats were sacrificed at various times after surgery, and anastomotic healing was assessed by measurement of breaking strength and histological examination. On the 3rd day after operation, the breaking strength of anastomoses in these 3 groups decreased to the lowest values, but no statistical differences were noted. On the 7th day or 14th day, increased resistance to breaking developed in all 3 groups and was greatest in the thermally treated groups. Histological findings supported these results. However, restoration of normal body weight after surgery was significantly delayed in the thermally treated groups. Thus, it appears that local hyperthermia within the limits of 44.0ﾟC x 30 min. had no adverse effects on the healing of intestinal anastomoses.
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