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1989 Fiscal Year Final Research Report Summary

Experimental Study of the Influence of Intraperitoneal Thermochemotherapy on the Healing of Intestinal Anastomoses

Research Project

Project/Area Number 63480305
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTottori University

Principal Investigator

MAETA Michio  Tottori University Assistant Professor, 医学部, 講師 (70032208)

Co-Investigator(Kenkyū-buntansha) HAMAZOE Ryuichi  Tottori University Assistant, 医学部, 助手 (40156394)
SHIMIZU Morio  Tottori University Assistant Professor, 医学部附属病院, 講師 (40108808)
Project Period (FY) 1988 – 1989
KeywordsPeritoneal dissemination / Intestinal anastomosis / Continuous hyperthermic peritoneal perfusion / Wound healing / Intraabdominal thermochemotherapy
Research Abstract

When hyperthermia is applied in the peritoneal cavity after surgery, it is important to ask whether or not it interferes with the subsequent healing of intestinal anastomoses. To study this problem, rats with intestinal anastomoses were prepared and divided into 3 groups. In group A, local hyperthermia (44.0゚C x 30 min.) was applied to the intestinal loop that containes anastomoses using saline. in group B, local hyperthermia (44.0゚C x 30 min.) was applied using saline supplemented with Mitomycin C (MMC; 10 mg/L). In the control group, no thermal treatment was applied. In each groups, rats were sacrificed at various times after surgery, and anastomotic healing was assessed by measurement of breaking strength and histological examination. On the 3rd day after operation, the breaking strength of anastomoses in these 3 groups decreased to the lowest values, but no statistical differences were noted. On the 7th day or 14th day, increased resistance to breaking developed in all 3 groups and was greatest in the thermally treated groups. Histological findings supported these results. However, restoration of normal body weight after surgery was significantly delayed in the thermally treated groups. Thus, it appears that local hyperthermia within the limits of 44.0゚C x 30 min. had no adverse effects on the healing of intestinal anastomoses.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Michio Maeta: "The effect of angiotensin II on blood flow in tumors during localized hyperthermia" Int J Hyperthermia. 5. 191-197 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古賀成昌: "胃癌の温熱療法-特に腹膜播種性転移を中心に-" Pharma Medica. 7. 81-87 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 貝原信明: "漿膜浸潤陽性胃癌の術後腹膜再発防止対策としての持続温熱腹膜灌流療法" 日本消化器外科学会誌. 22. 1001-1004 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuaki Kaibara: "Hyperthermic peritoneal perfusion combined with anticancer chemotherapy as prophyloctic treatment of peritoneal recurrence of gastric cancer" Hepato-Gastroenterology. 36. 75-78 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清水哲: "消化管吻合部の創傷治癒に及ぼす温熱の影響に関する研究" 最新医学. 44. 1979-1981 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsu Shimizu: "The influence of local hyperthermia on the healing of small-intestinal anastomoses in the rat" 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Michio Maeta: "Hyperthermic Oncology,1988,Vol.2" Taylor & Francis,London,New York,Philadelphia,eds.T.Sugahara & M.Saito, 5 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ryuichi Hamazoe: "Hyperthermic Oncology,1988,Vol.1" Taylor & Francis,London,New York,Philadelphia,eds.T.Sugahara & M.Saito, 2 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Michio Maeta: "The effect of angiotensin II on blood flow in tumors during localized hyperthermia." Int J Hyperthermia 5(2), 191-197, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shigemasa Koga: "Hyperthermia for gastric cancer-peritoneal dissemination." Pharma Medica 7: 81-87, 1989(in Jpn).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuaki Kaibara: "Continuous hyperthermic peritoneal perfusion as a prophylactic therapy of peritoneal recurrence for gastric cancer with serosal invasion." Jpn J Gastroenterol Surg 22, 1001-1004, 1989(in Jpn).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuaki Kaibara: "Hyperthermic peritoneal perfusion combined with anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer." Hepato-Gastroenterology 36, 75-78, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsu Shimizu: "Effect of local hyperthermia on the healing of small-intestinal anastomoses." Saishin Igaku 44, 1979-1981, 1989(in Jpn).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsu Shimizu: "The influence of local hyperthermia on the healing of small-intestinal anastomoses in the rat."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Michio Maeta: Hyperthermic Oncology 1988, Vol.2. Taylor & Francis, 5 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ryuichi Hamazoe: Hyperthermic Oncology 1988, Vol.1. Taylor & Francis, 2 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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