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1990 Fiscal Year Final Research Report Summary

Early and Late Change in the Pancreas Following Acute Pancreatitis -Relations Between Acute and Chronic Pancreatitis

Research Project

Project/Area Number 63480306
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionShimane Medical University (1990)
Nagasaki University (1988-1989)

Principal Investigator

TSUCHIYA Ryoichi  Shimane Med. Univ., 副学長 (70025534)

Co-Investigator(Kenkyū-buntansha) NISHIURA Kiyoaki  Nagasaki Univ., 医学部附属病院, 医員
TOKUNAGA Shigeki  Nagasaki Univ., 医学部附属病院, 医員
MAEDA Harunobu  Nagasaki Univ., 医学部, 講師 (10211559)
IZAWA Kunihide  Nagasaki Univ., 医学部附属病院, 助教授 (40124820)
TSUNODA Tsukasa  Nagasaki Univ., 医学部, 助教授 (00110841)
Project Period (FY) 1988 – 1990
KeywordsAcute pancreatitis / Chronic pancreatitis / Experimental pancreatitis / Deoxycholic acid / 自家胆汁
Research Abstract

The purpose of this study is to clarify whether chronic pancreatitis may follow acute pancreatitis or not. Acute pancreatitis was induced in dogs by the intraductal injections of 10% deoxycholic acid (DCA) through a silicone tube, which had been inserted from the tail of the pancreas. The dogs were divided into 4 groups.
Groupe 1 : 4 dogs with acute edematous pancreatitis induced by a single injection of DCA
Group 2 (1) : 5 dogs with acute edematous pancreatitis by low pressure injection of DCA 4 times at 1 week interval
Group 2 (2) : 3 dogs with acute hemorrhagic pancreatitis by high pressure injections of DCA 4 times at 1 week interval
Control group : 4 dogs with saline injection 4 times at 1 week interval In each dog, caelurein-secretin test and intravenous glucose tolerance test were done at the discretion of time. After completion of the experiment, the dogs were killed and pathological studies were performed.
There were no significant changes of the results of caelurein-secretin test and intravenous glucose tolerance test between any groups. With regard to pathological lesions, inter- and intralobular collagen fibers in the pancreatic tissue in group 1 were increased 1 week after the injection, but 3 weeks after the injection the inter- and intralobular collagen fibers were decreased. In group 2 (1), the similar pathological changes to group 1 were seen but the changes were still observed 8 weeks after the injections. In group 2 (2), a marked increase of inter- and intralobular collagen fibers and replacement of pancreatic lobes by fibrosis were observed even in the 16th week after the injections.
In conclusion, it is suggested that acute pancreatitis induced by repeated intraductal injection of DCA could result in chronic pancreatitis.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 前田 治伸: "重症急性膵炎の後期合併症の診断と治療" 日本臨床. 48. 195-200 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 角田 司: "急性膵炎の外科治療" 腹部救急診療の進歩. 10. 90-94 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松元 定次: "炎症性膵嚢胞の自然経過と外科治療" 胆と膵. 11. 81-85 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 浦 一秀: "膵臓・脾臓・門脈副腎手術の術後管理ー膵嚢胞の手術ー" 外科治療. 62. 870-872 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松元 定次: "膵仮性嚢胞の治療と成績" 膵臓. 5. 137-139 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田 治伸: "急性膵炎発症後の膵変化ー特に慢性膵炎との関連についてー" 病態生理. 9. 830-832 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松崎 純宏: "抗生物質の膵液への移行ーLMOX(Latamoxef)について" 胆と膵. 11. 1055-1059 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松尾 繁年: "消化器病セミナ-39:重症急性膵炎" ヘルス出版, 16 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda H, et al: "Diagnosis and clinical managements of late complications of severe acute pancreatitis" Japanese J. Clinical Medicine. 48(1). 195-200 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunoda T, et al: "Surgical treatment for acute pancreatitis" Progress in Abdominal Emergency Medicine. 10(1). 90-94 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumoto T, et al: "Natural history and surgical management of inflammatory pancreatic cysts" J. Biliary Tract and Pancreas. 11(1). 81-85 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ura K, et al: "Surgery for pancreatic cyst" Surgical Therapy. 62(6). 870-872 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumoto T, et al: "Therapy of pancreatic pseudocysts" J. Japan Pancreas Society. 5(1). 137-139 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda H. et al: "Early and late changes in the pancreas following acute pancreatitis - Relations between acute and chronic pancreatitis-" Medicina Philosophica. 9(10). 830-832 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuzaki S, et al: "Pancreatic excretion of LMOX (Latamoxef)" J. Biliary Tract and Pancreas. 11(9). 1055-1059 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuo S, et al: "Surgical therapy ; Vicissitudes of operative indication and various procedures for severe acute pancreatitis" Seminar for Gastroenterology. 39. 159-174 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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