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1990 Fiscal Year Final Research Report Summary

Studies of Extracorporeal Membrane Oxygenation (ECMO) for Neonatal Acute Respiratory Failure

Research Project

Project/Area Number 63480319
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionUniversity of Nagoya School of Medicine (1988, 1990)
Kobe University (1989)

Principal Investigator

ITO Takahiro  University of Nagoya, School of Medicine, Dept. of Surgery, Branch Hospital, Professor, 医学部, 教授 (10022899)

Co-Investigator(Kenkyū-buntansha) TAKAGI Hiroyuki  Cyuhkyoh Hospital, Dept. of Research, Head, 研究部, 部長
IIO Kenji  University of Nagoya, School of Medicine, Dept. of Surgery, Branch Hospital, Ass, 医学部, 助手 (10184334)
Project Period (FY) 1988 – 1990
KeywordsECMO / VA-bypass / membrane oxygenation / neonatal respiratory failure
Research Abstract

Conventional ECMO circuits with a roller pump are not always free from serious mechanical problems like venous collapse, air embolism, burst of the arterial line. A new, safer, and more practical ECMO circuit with an automatic blood pump was developed. Our neonatal ECMO circuit primed 65 ml consisted of blood pumps with 4 mm ball valves and a membrane oxygenator of 0.5 sq.m. Our pediatric ECMO circuit primed 120 ml with 6 mm valves and a membrane oxygenator of 0.8 sq.m. The pump could change output automatically in response to its filling and thereby did not produce excessive negative pressure.
Our ECMO circuits had been extensively tested on a mock circulation system and used on dogs. No mechanical problem had been encountered in continuous driving on the mock circulation system for 21 days. Bypass flow changed automatically in response to venous return, but remained constant against changes in arterial pressure.
Effect of ECMO using our automatic blood pumps on hemodynamics was studied on 50 dogs. During VA-ECMO mean pulmonary arterial pressure and right ventricular pressure decreased. When the flow increased more than 50 ml/kg/min, the aortic systolic pressure tended to decrease more significantly than the systolic left ventricular pressure. The endodiastric pressure in both right and left ventricles elevated at high bypass flow. These findings indicated that VA-ECMO of high frow caused ventricular strain.
In conclusion, our automatic ECMO circuit is a safe and useful device treating small infants with acute respiratory failure but VA-ECMO flow should be kept as little as possible because of possible ill effects on the heart.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 瀬尾 孝彦,伊藤 喬廣 他: "改良型高木式ポンプを用いた小児用自動制御ECMO装置の開発" 人工臓器. 20. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Seo,T.Ito,H.Takagi,K.Iio,J.Kato: "Experimental Study on the hemodynamic effects of venoーarterial extracorporeal membrane oxygeration (VAーECMO) with on autcmatically driver blood pump on pappies." Artificial Organs. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 瀬尾 孝彦,伊藤 喬廣 他: "先天性模隔膜ヘルニアに応用可能な新生児用ECMO回路の試作" 小児外科. 22. 793-799 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ito,T.Seo,H.Takagi: "New neonatal and pediatric vencarterial extracorporeal membrane oxygenation circuit using automatically driven blood pumps." Artificial Organs. 14. 186-188 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seo T., Ito T., et al :"Development of the new ECMO system for children using the modified Takagi's blood pump." Jpn J Artificial Organs. 20 :. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seo T., Ito T., et al :"Experimental study on the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with an automatically driven blood pump on puppies." Artificial Organs. 15 :. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seo T., Ito T., et al :"Development of new ECMO circuit applied to congenital diaphragmatic hernia." Jpn J Pediatr Surg. 22 :. 793-799 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito T., Takagi H., et al :"New neonatal and pediatric veno-arterial extracorporeal membrane oxygenation circuit using automatically driven blood pumps." Artificial Organs. 14(Suppl) :. 186-188 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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