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1990 Fiscal Year Final Research Report Summary

Immunohistological Study for Head and Neck Cancer

Research Project

Project/Area Number 63480383
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionJichi Medical School

Principal Investigator

MORITA Mamoru  Jichi Medical School, Dept. of Otolaryngology. Professor., 医学部, 教授 (00048969)

Co-Investigator(Kenkyū-buntansha) INOUE Ko  Jichi Medical School, Dept. of Otolaryngology, Assistant., 医学部, 助手 (60213154)
FUJIMOTO Yasuyuki  Jichi Medical School, Dept. of Otolaryngology, Assistant., 医学部, 助手 (80209105)
IGARASHI Masahito  Jichi Medical School, Dept. of Otolaryngology, Assistant., 医学部, 助手 (30201304)
ISHIDA Takashi  Jichi Medical School, Dept. of Otolaryngology, Lecturer., 医学部, 講師 (10151375)
MIYATA Mamoru  Jichi Medical School, Dept. of Otolaryngology, Lecturer., 医学部, 講師 (50159175)
Project Period (FY) 1988 – 1990
KeywordsMaxillary cancer / Combined therapy / Histopathology / NonーHodgkin lymphoma / Immunohistology
Research Abstract

1. Immunohistological Study of the Maxillary Cancer. Examined materials were biopsy specimens obtained from the maxillary sinus during the course of a therapy of simultaneous combined radiation and regional chemotherapy. Surgical specimens obtained 2 to 4 weeks after the combined therapy were also examined. All cases were squamous cell carcinoma. A degree of interstitial cell infiltration surrounding cancer cells nests was observed in cases of well differentiated type. During the course of the combined therapy, amount of interstitial cell infiltration was suppressed, which continued until surgery. Mean doses of radiation and regional chemotherapy were 24Gy and 6 times (1.5g of 5FU) respectively. These doses is less than half of generally accepted doses. In 70% of the cases, however, severe degeneration of cancer cells was observed. These findings suggest that the interstitial cells surrounding cancer cell nests play a important role in cancer cell degeneration. Immunohistological examination revealed that the greater part of these infiltrated interstitial cells consisted of T cells. Concerning functions of T cell subclasses i. e. suppressor/cytotoxic or helper/inducer are under exaination.
2. Revision of Non-Hodgkin Lymphoma. Cases of nonーHodgkin lymphoma were reーexamined from the stand point of LSG-classification, T/B-cell differentiation, Stage classification and prognosis. A half of reーexamined cases consisted of diffuse large cell type (D. L.) and 20% of the cases were diffuse medium cell type (D. Med.). T/B-cell differentiation revealed that 80% of the cases consisted of B cell type. Cases originated from Waldeyer's ring and nasalーparanasal region showed worse prognosis than cases originated from neck regions. Insufficient estimation concerning histopathological as well as stage classification results inadequate therapy and poor prognosis. In applying of appropriate chemotherapy, prognosis of recent cases is qradually improving.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 森田 守: "上顎洞癌の併用療法" 日本耳鼻咽喉科学会誌. 92. 169-175 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森田 守: "上顎洞癌T4症例の頭蓋底郭清法" 耳鼻咽喉科・頭頚部外科. 61. 588-589 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morata M, et al: "A combined treatment for carcinoma of the maxillary sinus. -Treatment method for T4 casesー." J Otolaryngol Jpn. 92. 169-175 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita M: "A method of skull base dissection for T4 cases of carcinoma of the maxillary sinus." Otolaryngol H & N Surg (Tokyo). 61. 588-589 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita M, Miyata M: "Combined treatment for carcinoma of the maxillary siuns." Proceedings of the XIV World Congress of Otorhinolarygology, Head and Neck Surgery, Madrid, Spain, September. 10-15 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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