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1990 Fiscal Year Final Research Report Summary

Experimental Study on Hearing Impairment in Acoustic Neuromas

Research Project

Project/Area Number 63480385
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

KANZAKI Jin  Keio University School of Medicine, Professor, 医学部・耳鼻咽喉科, 教授 (00051441)

Co-Investigator(Kenkyū-buntansha) OGAWA Shigeo  Keio University School of Medicine, Instructor, 医学部・耳鼻咽喉科, 助手 (10177131)
KUNIHIRO Takanobu  Keio University School of Medicine, Instructor, 医学部・耳鼻咽喉科, 助手 (10170010)
OGAWA Kaoru  Keio University School of Medicine, Instructor, 医学部・耳鼻咽喉科, 助手 (00169179)
Project Period (FY) 1988 – 1990
KeywordsAcoustic Neuroma / Hearing Impairmet / Hypoxia / Cochlear Blood Flow / Steroid Hormone / Hypothermia
Research Abstract

The relationship between cochlear blood flow (CBF) and cochlear electrical activity was investigated to better understand cochlear circulatory insufficiency, which is considered to be a cause of hearing loss acoustic neuroma.
1. Experimental animal models for cochlear circulatory insufficiency
Experimental animal models for cochlear circulatory insufficiency were made by asphyxia, NO2 anoxia and obstruction of AICA.
Changes in systemic blood pressure (BP) during asphyxia and NO2 anoxia were clearly associated with changes in CBF. At the initial stage of asphyxia, however, CBF did not change in spite of the decrease in BP. These discrepancies appeared to be related to autoregulation of CBF. There was no difference in the change in compound action potential of the eighth nerve (AP) between asphyxia and NO2 anoxia.
Data from the experiment using AICA obstruction were insufficient to provide information on changes in AP as CBF decreased. However, the data indicated that the higher the CBF reduction rate, the higher the disappearing rate of AP.
2. Effects of steroid hormone and hypothermia on cochlear circulatory insufficiency
Although changes in CBF following systemic administration of steroid hormone were not clearly observed, the recovery time of N1 (AP) latency became shorter with systemic administration of steroid hormone. Similar results were obtained with hypothermia. Based on the analysis of these results, we concluded that the reversibility of the cochlear activity in cochlear circulatory insufficiency could be improved by the administration of steroid and hypothermia.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 小川 茂雄他: "蝸牛血流に対するステロイドの影響" Ear Res Jpn. 20. 319-320 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小川 郁他: "asphyxiaによる蝸牛血流の変化ー頂回転、基低回転の変化についてー" Ear Res Jpn. 20. 321-322 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanzaki J et al: "Hearing Presention in aoovstic newoma scogery and preoperative audiological findings" Acta Ohlaryngol(Stockh). 107. 474-479 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 神崎 仁: "聴神経腫瘍の外科的治療" 耳鼻展. 33. 201-528 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa S et al: "Effects of steroid hormone on cochlear blood flow." Ear Res Jpn. 20. 319-320 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa K et al: "Effect of asphyxia on cochlear blood flow comparison between in apical turn and basal turn-." Ear Res Jpn. 20. 321-322 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanzaki J et al: "Hearing preservation in acoustic neuroma surgery and preoperative audiological findings." Acta Otolaryngol (Stock). 107. 474-479 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanzaki J et al: "Surgical management of acoustic neuromas." ORL Tokyo. 33. 201-528 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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