1989 Fiscal Year Final Research Report Summary
Study on Early Pathology of Senile Disciform Macular Degeneration using a computerized image-processing system
| Project/Area Number |
63480398
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
MATSUI Mizuo Nihon Univ. School of Medicine, Professor, 医学部, 教授 (50058913)
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| Co-Investigator(Kenkyū-buntansha) |
YAO Masaaki Nihon Univ. School of Medicine, Assistant, 医学部, 助手
EGAWA Tomoko Nihon Univ. School of Medicine, Assistant, 医学部, 助手
HAGITA Katsuhiko Nihon Univ. School of Medicine, Assistant, 医学部, 助手
YAZAWA Mitsuko Nihon Univ. School of Medicine, Instructor, 医学部, 講師
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| Project Period (FY) |
1988 – 1989
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| Keywords | fluorescein angiography / contrast enhancement / image processing / age - related macular degeneration / senile macular degeneration / age - related RPE pathologies / hard drusen / diffuse drusen |
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| Research Abstract |
In order to obtain more detailed information for early stage diagnosis of age- related pathologies at the posterior pole of the eye- ground, an image processing procedure was applied to fluorescein angiographs from 61 patients over 50 years of age : 38 patients with the neovascular type of age-related macular degeneration ARMD (senile disciform macular degeneration SDMD) and 23 patients with ARMD without choroidal neovascularization. For the image processing to enhance contrast, spatially - variant contrast enhancement using local range modification was applied.
On the enhanced angiographs larger numbers of drusen were demonstrated than on the regular angiographs, making smaller drusen observable and giving the angiographs of low quality higher resolution. In some patients, widely scattered dot or granular hyperfluorescence became observable. This hyperfluorescence might represent diffuse drusen (Green, W.R.) or basal laminar deposits (Sarks, S.). On the enhanced angiographs some soft drusen came to show lack of uniformity in their hyperfluorescence.
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