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1991 Fiscal Year Final Research Report Summary

Functional-Morphological Studies for Aging Changes in Ocular Accommodation

Research Project

Project/Area Number 63480399
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionAichi Medical University

Principal Investigator

NISHIDA Shozo  Aichi Medical University Medical School, Professor, 医学部, 教授 (10065526)

Co-Investigator(Kenkyū-buntansha) MOCHIZUKI Miyuki  Aichi Medical University Medical School, Assistant, 医学部, 助手 (70200334)
KABAYAMA Chikara  Aichi Medical University Medical School, Assistant, 医学部, 助手 (80185967)
ARIKI Gen  Aichi Medical University Medical School, Assistant, 医学部, 助手 (20184286)
ATSUMI Kazunari  Aichi Medical University Medical School, Instructor, 医学部, 講師 (30148316)
MIZUTANI Satoshi  Aichi Medical University Medical School, Assistant, 医学部, 助手 (60166014)
Project Period (FY) 1988 – 1990
KeywordsAccommodative amplitude / Lens thickness / Depth of anterior chamber / Human ciliary muscle / monkey ciliary muscle / Accommodative contraction / Cilaary muscle myofilament / Lens fiber / Aging change / 加齢変化
Research Abstract

Morphological change of the ciliary muscle and crystalline lens(lens)were investigated in relation to the prebyopia. 1)Pattern analysis of objective accommodogram indicated larger accommodative amplitude by step stimuli than by continuous stimuli and marked decrease of the amplitude between 35 to 39 and 40 to 44 years of age by continuous stimuli. 2)The lens showed continuous increases of thickness with age and by accommodative contraction and the thickness in the fifties was as same as the accommodatively contracted lens in the twenties. The anterior chamber continuously decreased in depth with age. 3)Human and monkey ciliary muscles decreased their size and increased connective tissue ratio with age. The circular muscle fiber of both species increased their ratio by 70 years of old in the human-eye and 20 years of old in the monkey. 4)Accomodative contraction by pilocarpine caused increases of the muscle width and shifting of the ciliary muscle toward the axial-and-anterior direction of the monkey eye. 5)Lipofuscin granules in the human and monkey ciliary muscle cell showed age-dependent increase in number. 6)Freeze-fracture technique disclosed that myofilaments in the monkey ciliary muscle cell had direct connection with cell and nuclear membranes. 7)Increased relative ratio of newly formed cortical lens fibers suggested a possibility which might cause decrease of the lens elastisity with age.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 西田 祥蔵,水谷 聡: "ヒト毛様体筋のtopography" 日眼会雑誌. 95. 1044-1056 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 近藤 三博,樺山 力,西田 祥蔵: "サル毛様体筋のフリ-ズフラクチュアおよびエッチング像について" 日眼会雑誌. 96. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹本 喜也,勝 安彦,水谷 聡,西田 祥蔵: "サル眼前房隅角線維柱帯の形態的研究ー自律神経作働薬の影響について" あたらしい眼科. 7. 881-885 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 駒井 昇,西田 祥蔵: "走査電子顕微鏡で観察したサル水晶体細胞の加齢変化" 眼紀. 41. 1924-1929 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo,M.and Nishida,S.: "Freeze-Fracture and Deep-Etching of Monkey Ciliary Muscle Cells" J.Clin.Electron Microscopy. 23. 962-963 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西田 祥蔵: "眼組識の老化と調節 老視の進行と毛様体筋の組識変化" 医学のあゆみ. 155. 730 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishida, S.: "Fine structure in the anterior originating region of the human ciliary muscle." Journal of the Eye. 5(5). 739-742 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitagawa, K. Nishida, S. and Ogura, Y.: "In vivo quantitation of autofluorescence in human retinal pigment epithelium." Ophthalmologica. 199(2-3). 116-121 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashima, A., Nishida, S. et al.: "Age-dependent changes of lens crystallins in hereditary cataract (ICR/1 strain) rat." Journal of the Eye. 6(8). 1235-1238 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsu, Y., Atsumi, K. and Nishida, S.: "Accommodation responses to step stimuli." Journal of the Eye. 6(12). 1857-1878 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishida, S.: "Aging changes of ocular tissues and their influences on accommodative function." Acta Soc. Ophthalmol. Jpn.94(2). 93-119 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takemoto, Y., Katsu, Y., Mizutani, S. and Nishida, S.: "A morphological study on the monkey trabecular." Journal of the Eye. 7(6). 881-885 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komai, N. and Nishida, S.: "Scanning electron microscopic study on morphological changes in the monkey crystalline lens cell with age." Folia Ophthalmol. Jpn.41(10). 1924-1929 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo, M. and Nishida, S.: "Freeze-fracture and deep-etching of monkey ciliary muscle cells." J. Clin. Electron Microscopy. 23(5-6). 962-963 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishida, S. and Mizutani, S.: "Topography of the human ciliary mucle." Acta Soc. Ophthalmol. Jpn.95. 1044-1056 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo. M. and Nishida, S.: "Freze-fracture and deep etch replica of monkey ciliary muscle." Acta Soc. Ophthalmol. Jpn.96. 1992

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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