1990 Fiscal Year Final Research Report Summary
A Basic Study of New Medical Therapy for Glaucoma to Improve Blood Supply to the Optic Nerve Head
| Project/Area Number |
63480400
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
AZUMA Ikuo Osaka Medical College Department of Ophthalmology, Profossor, 医学部, 教授 (30084817)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Bunpei Osaka Medical College Department of Ophthalmology, Assistant, 医学部, 助手 (10183386)
TOKUOKA Satoru Osaka Medical College Department of Ophthalmology, Assistant, 医学部, 助手 (80155514)
MATSUDA Kimio Osaka Medical College Department of Ophthalmology, Assistant, 医学部, 助手 (60165826)
NAKAJIMA Masayuki Osaka Medical College Department of Ophthalmology, Associate Profexxor, 医学部, 講師 (00140161)
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| Project Period (FY) |
1988 – 1990
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| Keywords | glaucoma / thermography / intraocular blood flow / alpha-1 blocker / medical treatment |
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| Research Abstract |
A) Investigations were made on the cold response of skin and eye temperature in glaucoma to detect the abnormality of autonomic nerve system, and the following results were obtained : The skin temperature was measured using thermometer before and after exposure to ice water in normals, ocular hypertension (OH) , Primary Open-Angle Glaucoma (POAG) patients and Low Tension Glaucoma (LTG) patients. The temperature at the corneal center was measured via thermography (INF-160, product of Nihon Koden) before and after instillation of 40 drops of icy saline. There was no difference in skin temperature in LTG, POAG, OH and normal subjects before cold exposure of skin. However, skin temperature recovery rate decreased in LTG, POAG and OH, in order of delay. The corneal temperature before examination was statistically low in LTG and POAG. The delay was observed in the initial phase of temperature recovery in LTG, POAG and OH. These observations suggest the disturbance of sympathetic nerve function and the decrease of ocular circulation in glaucomatous eyes, especially in LTG.
B) Then, we tried to introduce the new anti-glaucomatous drug, alpha-1 blocker, for the treatment of glaucoma. The effect of Bunazosin hydrochloride, a selective alpha-1 blocker, on intraocular pressure and ocular blood flow was observed basically and clinically. A significant reduction of intraocular pressure and the improvement of blood flow was found after topical application of Bunazosin solution. The use of Bunazosin in the treatment of glaucoma may have high potential.
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