1989 Fiscal Year Final Research Report Summary
Helix Stability and Transition Behavior of Helix Sense of Polypeptide
| Project/Area Number |
63550663
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子物性
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
TSUJITA Yoshiharu Nagoya Institute of Technology, Dept. of Materials Science and Engineering, Professor, 工学部, 教授 (70016591)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Takatoshi Nagoya Institute of Technology, Dept. of Materials Science and Engineering, Lect, 工学部, 講師 (60135407)
TAKIZAWA Akira Nagoya Institute of Technology, Dept. of Materials Science and Engineering, Prof, 工学部, 教授 (90016262)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Polypeptide / Helix Stability / Helix Sense / alpha Helix / Circular Dichroism / Polyglutamic Acid Ester / Polyaspartic Acid Ester |
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| Research Abstract |
Polyaspartic acid esters have unstable and reversed helix sense to stable Polyglutamic acid esters because of its competitive hydrogen bond between NH group in backbone and C=O group in side chain. The object of a present study is to clarify helix stability and helix sense of polyaspartic acid esters through the interaction of side chain - backbone and side chain.
Various copolyaspartic acid esters were synthesized and its circular dichroism spectra in solution and solid state were examined as a function of composition and temperature. Left handed helix of polyaspartic acid benzyl esters transformed to right handed helix by the replacement of benzyl to alkyl group except for methyl group. Furthermore copolyaspartic acid esters with low alkylation transformed to right handed alpha helix sense with increasing temperature. These behavior is interpreted in terms of the competitive hydrogen bond between backbone and side chain.
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