| Project/Area Number |
63570020
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
HIRAI Kei-ichi Kanazawa Medical University, Anatomy, Professor, 医学部, 教授 (60027092)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Tadashi Kanazawa Medical Univeraity, Anatomy, Instructor, 医学部, 助手 (80151794)
MORIGUCHI Keiiichi Kanazawa Medical University, Anatomy, Lecture, 医学部, 講師 (30139779)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Trachea / Bronchiole / Tracheal graft / Mycoplasma / Peroxidase / Bronchial asthma / Eosinophil / Collagen |
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| Research Abstract |
1. A longitudinal patch window was made on the cervical trachea in dogs, and replaced by a polypropylene mesh graft. From the cut edge, flat, poorly differentiated cells migrated, spread on the newly formed stroma and formed atypical epithelium. Collagen coating of the graft, however, allowed fibroblasts to produce normal connective tissue and epithelium to regenerate normal composition.
2. The tracheal columnar epithelial cells of SPF rats were entirely devoid of peroxidase activity through the growth from fetus to adult.
3. Mycoplasmal infection to the respiratory tract induced peroxidase synthesis in ciliated cells and mucous secretory cells. The latter released the peroxidase as a probable defense mechanism.
4. Mycoplasmal infection to the rat respiratory tract resulted in the peritoneal eosinophil activation in that degranulation of EPO was enhanced 5-times.
5. Peripheral blood eosinophils of children with bronchial asthma had been activated and showed a leakage and release of EPO. The blood plasma from mycoplasma-infected patients stimulated the EPO release in the eosinophils of normal donors and asthmatic patients.
6. It was noted an increase in eosinophil stimulating substances in the blood plasma of mycoplasma-infected patients.
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