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1989 Fiscal Year Final Research Report Summary

Physiological roles in neutral and humoral control of venous system

Research Project

Project/Area Number 63570036
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionShinshu University School of Medicine

Principal Investigator

OHHASHI Toshio  Shinshu University, Dept. Physiol. Prof., 医学部, 教授 (80020832)

Co-Investigator(Kenkyū-buntansha) FUKUSHIMA Sachiyo  Shinshu Univ. Dept. of Physiol. Res. ass., 医学部, 助手 (30020788)
MATSUKI Takamichi  Shinshu Univ. Dept. of Physiol. Res. ass., 医学部, 助手 (30199773)
KAWAI Yasuaki  Shinshu Univ. Dept. of Physiol. ass. Prof., 医学部, 助教授 (70143972)
Project Period (FY) 1988 – 1989
KeywordsDog / Rabbit / Monkey / adrenergic fibers / vasoconstrictive agents / vasodilative agents / venous smooth muscles / veins
Research Abstract

To evaluate the mode of neural and humoral control on venous smooth muscles, we have undertaken to study regional differences in the density of aminergic nerve fibers of the rabbit, canine, and monkey venous walls by glyoxylic acid-histochemical techniques, and in the potency in vasoconstrictive and vasodilative responses of isolated canine and monkey smooth muscles. The experimental results are summarized as follows: (1) The aminergic nerve fibers innervate most densely in the portal vein, inferior caval vein, renal vein, and common iliac vein. (2) The nerve fibers present sparsely in the venous walls of femoral vein and lateral saphenous vein at the intramuscular portion. (3) The heterogeneity in the aminergic innervation was observed in the monkey, canine, and rabbit venous system, but the density of aminergic nerve fibers was highest in the monkey veins and lowest in the rabbit. (4) There were marked heterogeneity in pharmacological responses to vasoconstrictive and vasodilative agents in isolated monkey and canine veins. (5) Thus, from the pharmacological points of view, the responsiveness of venous smooth muscle was divided as following three groups: (1) abdominal caval vein, iliac veins, renal vein, and portal vein; (2) thoracic caval vein, extremity veins, and cervical veins; (3) axillar vein and subclavian vein. (6) In monkey venous system, the third group was not distinguished, therefore the third grouped veins may be a characteristic feature of the pharmacological responses of venous smooth muscles in animal with four extremities, comparing with monkey and human being.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 大橋俊夫: "静脈系の機能と形態" 呼吸と循環. 37. 127-135 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河合康明、大橋俊夫: "ANPの血管弛緩作用" 脈管学. 28. 1159-1162 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KAWAI,Y.,OHHASHI,T.: "Heterogeneity in responses of isolated monkey arteries and veins to atrial natriwotic peptide" Cam.J.Physiol.Pharmacol. 67. 326-330 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KAWAI,Y.,OHHASHI,T.: "Age-related changes in relaxant response of vascular smooth muscles to atrial natriuretic peptide" J.Pharmacol.Exp.Ther. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OHHASHI,T.,WATANABE,N.,KAWAI,T.: "Effects of atrial natriuretic peptide on isolated bovine mesenteric lymphaties" Am.J.Physical.(1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OHHASHI,T.,YOSHINAKA,S.: "Physiological roles of vasa vasorum on micro-and macromolecular transport through aortic walls with special reference to the topography of a therosderotic plaques." Proc.N.Y.Aced.Sci.(1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohhashi, T.: "Functional and morphological characteristics in venous system (in Japanese)" Kokyu to Junkan, 37;127-135, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawai, Y. and Ohhashi, T.: "Vasorelaxant responses of isolated arteries and veins to ANP (in Japanese)" J. Jpn. Coll. Angiol. 28;1159-1162, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawai, Y. and Ohhashi, T.: "Heterogeneity in responses of isolated monkey arteries and veins to ANP" Can. J. Physiol. Pharmacol. 67;326-330, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawai, Y. and Ohhashi, T.: "Age-related changes in relaxant responses of vascular smooth muscles to ANP" J. Pharmacol. Exp. Ther.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohhashi, T., Watanabe, N. and Kawai, Y.: "Effects of atrial natriuretic peptide on isolated bovine mesenteric lymphatics" Am. J. Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohhashi, T. and Yoshinaka, S.: "Physiological roles of vasa vasorum on micro- and macro- molecular transport through aortic walls with special reference to topography of atherosclerotic plaques." Proc. N.Y. Acad. Sci.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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