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1990 Fiscal Year Final Research Report Summary

Neuropathological Study of HTLV-I Related Diseases- Adult T-cell Leukemia (ATL) and HTLV-I Associated Myelopathy (HAM)

Research Project

Project/Area Number 63570146
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKagoshima University

Principal Investigator

SATO Eiichi  Kagoshima University Faculty of Medicine, Professor, 医学部, 教授 (60004579)

Co-Investigator(Kenkyū-buntansha) GOTO Masamichi  National leprosarium Hoshizuka-Keiaien, Division of research and examination, 研究検査科, 科長
HASUI Kazuhisa  Kagoshima University Faculty of Medicine, Lecturer, 医学部, 講師 (70198703)
Project Period (FY) 1988 – 1990
KeywordsHTLV-I / HTLV-I associated / Retrovirus / Adult T-cell leukemia (ATL) / myelopathy / Neuropathology / Immunohistochemistry
Research Abstract

Following studies were performed in order to elucidate the neurological disorders observed in ATL and pathogenesis of HAM. (1) Neurological signs are frequently observed in ATL. Systemic neuropathological study of 41 ATL patient autopsied revealed direct infiltration of leukemic cells in the brain and spinal cord, which were closely related to drowsiness and dementia. Some cases showed giant cells or AIDS-like vacuolar myelopathy, but inflammatory lesions compatible with HAM was not detected in the spinal cord of ATL cases. (2) Based on the hypothesis that migration of HTLV-I infected activated T-cell into the spinal cord through blood-brain barrier is important for the pathogenesis of HAM, population of UCHL-I positive T-cells in the spinal cords of HTLV-I carrier (n=4), non-carrier (n=7), non-endemic area cases (n=17) was semiquantitatively examined. However, there was no significant difference among them. On the contrary, a conventional neuropathology negative clinical HAM case showed more than 3 times increase of T-cells. (3) Distribution of HTLV-I gene in various organs of a HAM case was studied by Polymerase Chain Reaction (PCR) using Tax coding SK45. The spinal cord, sciatic nerve, psoas muscle, lung and liver were Tax positive, while cerebrum, cerebellum, midbrain, pons and kidney were negative. HTLV-I seems to be related to multi-organ inflammatory disorders.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 後藤 正道: "成人T細胞白血病・リンパ腫(ATLL)剖検例の中枢神経病変" 日本病理学会会誌. 77. 238 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 後藤 正道: "成人T細胞白血病・リンパ腫(ATLL)剖検例の脊髄病変ーHAMとの比較" 神経病理学. 9. 134-135 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato E,et al: "Pathoepidemiological features of adult Tーcell lymphoma/leukemia in ad endemic area: Kagoshima,Japan" Cancer Detection and Prevention. 14. 423-429 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sueyoshi K: "Detection of proviral DNA in an autopsy of HTLVーI associated myelopathy (HAM)ーA polymerase chain reaction (PCR) study"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Goto M: "An autopsy case of HTLVーI associated myelopathy ^*HAM)with multiorgan inflammatory lesions"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Goto M: "Central nervous system lesions in adult T-cell leukemia." Nippon Byori Gakkai Kaishi. 77. 238-238 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goto M: "Spinal cord lesions in adult T-cell leukemia-comparison with HAM." Neuropathology. 9. 134-135 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato E: "Pathoepidemiological features of adult T-cell lymphoma/leukemia in and endemic area : Kagoshima Japan." Cancer Detection and Prevention. 14. 423-429 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sueyoshi K: "Detection of proviral DNA in an autopsy of HTLV-I associated myelopathy (HAM) -A polymerase chain reaction (PCR) study"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goto M: "An autopsy case of HTLV-I associated myelopathy (HAM) with multi-organ inflammatory lesions"

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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