1990 Fiscal Year Final Research Report Summary
Development of Psychobehavicral Performance Tests in the Assessment of Soivents Toxicity
| Project/Area Number |
63570260
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
MIYAKE Hirotsugu Sapporo Medical College, Department of Public Health Professor, 医学部, 教授 (20045363)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Tuyoshi same of the above School of Allied Health Profess. Professor, 衛生短期大学部, 教授 (00162446)
IKEDA Toshiko same of the above, 医学部, 講師 (00045410)
KISHI Reiko Sapporo Medical College, Department of Public Health, Asst. Professor, 医学部, 講師 (80112449)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Organic solvents / Central nervous system / Test battery / WHO core test / Painter / Cognitive function / HAND eye coordination / WAIS |
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| Research Abstract |
Subjects and Methods. Eighty-one male painters completed a symptom questionnaire. Twenty subjects underwent both questionnaire and neuropsychological examinations which consisted of a block design test (WAIS), digit symbol, digit span, Santa Ana motor coordination tests from the batteries of WHO-recommended neurobehavioral core test, as well as the reaction time, hand-eye motor coordination and Benton visual retention tests of the NES computerized test battery. The Profile of Mood Status (POMS) and a vocabulary test (synonym) were also included. Mean duration of exposure to organic solvents was 9.5 <plus-minus> 8.1 yrs. (range : 1-22). Toluene, mineral spirit and xylene were the major constituents of the paints used. Urine mandelic acids levels of workers was measured individually, and the mean value was 0.279<plus-minus>0.248 g/l (range was 0.063-0.7
Results. From the results of pairwise comparisons of the symptoms of the age-matched pairs of exposed and referent subjects, dry and scal
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y skin, easily depressed without reason, coldness of hands and legs, easily irritated without reason, loss of appetite, dizziness and unsteadiness occurred statistatistically significantly more often among the exposed subjects than among the referents. Matched analysis showed that performance of the Santa-Ana coordination and digit symbol were significantly lower than those of controls. In multiple regression models, controlling for age, education, vocabulary and alcohol intake, a significant relation was found only between solvent exposure and poor performance in the Santa-Ana coordination test with higher value of one of scale of POMS ('Confusion').
Conclusion. The results suggest that a symptom inquiry and POMS test are helpful for detecting the possible effects of exposure to low level of organic solvents. However no consistent pattern was observed in regard to the effects of organic solvent exposure on neurobehavioral function, which is coinncident with the type I toxic central nervous system disorder as classified by the WHO. Less
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