1989 Fiscal Year Final Research Report Summary
Pathophysiological studies of regulation and reserve of coronary circulation
| Project/Area Number |
63570402
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KOYANAGI Samon Kyushu University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (90128017)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOU Tetsuji Kyushu University, Faculty of Medicine, Research Associate, 医学部, 助手
TAKESHITA Akira Kyushu University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30038814)
|
|---|
| Project Period (FY) |
1988 – 1989
|
| Keywords | coronary blood flow / coronary reserve / Doppler-flow velocity |
|---|
| Research Abstract |
The purpose of the study was to investigate pathophysiology of the coronary circulation, particularly coronary flow reserve (CFR) in normal and pathological hearts using Doppler ultrasonic catheters.
1) Experimental studies. Recording of coronary blood flow velocity could be obtained with high accuracy by attaching the 20 MHz ultrasonic crystals to the tip of the catheters. The recordings were also possible in high-speed blood flow, such as reactive hyperemic response.
2) Coronary blood flow in humans. Coronary blood flow velocity was recorded in humans by Dopplercatheters. Safety of the devise during clinical application was also recognized. It was difficult to obtain absolute value of the flow volume, since the data of velocity were scattered too much in almost normal coronaries. However, it seemed that estimation of relative change of flow velocity was reliable. We confirmed the previous data that papaverine increases coronary blood flow in three-seven folds of normal resting values, and coronary flow reserve in pathological hearts may be estimated by the drug.
3) CFR in patients with angina pectoris. CFR was examined before and after PTCA in patients with angina pectoris. With decrease in severity of coronary stenosis CFR increased significantly even immediately after PTCA. There was significant inverse linear relationship between degree of coronary stenosis and CFR.
|
