1989 Fiscal Year Final Research Report Summary
DEVELOPMENT OF NEW DIAGNOSTIC AND THERAPEUTIC TECHNIQUES USING RADIOLABELED MONOCLONAL ANTIBODIES
| Project/Area Number |
63570489
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ENDO Keigo KYOTO UNIVERSITY, NUCLEAR MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (10115800)
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| Project Period (FY) |
1988 – 1989
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| Keywords | MONOCLONAL ANTIBODY / IMMUNOSCINTIGRAPHY / DIAGNOSTIC IMAGING / INDIUM-111 / COLORECTAL CANCER |
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| Research Abstract |
Anti-tumor monoclonal antibodies(MoAbs) are expected to carry radionuclides selectively to target tissues and to offer antigen-specific diagnosis. Indium-111 or Iodine-131 labeled MoAbs are clinically useful for the diagnosis of tumors in patients with malignant melanoma or colorectal cancer, acute myocardial infarction and vascular thrombosis using other corresponding MoAbs. The results of colorectal cancer using In-111 labeled ZCE-025 was encouraging, since it detected small tumors, tumors missed by CT and tumors in patients with normal serum CEA values. In whole series, acute or subacute toxicity was not observed. Use of human/mouse chimeric MoAbs or F(ab')_2, Fab fragments remarkably reduced the generation of human anti-mouse antibodies (HAMA). However, nonspecific uptake in liver and bone marrows limits the use of labeled MoAbs in the diagnosis and therapy. Techniques for labeling MoAbs with In-111 through the chelation with DTPA have allowed the chelating of various radionuciides useful for the radioimmunotherapy of cancer.
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[Publications] Keigo Endo, Yoichiro Matsuoka, Tetsuo Nakashima, Shingo Fujii, Mihoko Kunimatsu, Tsuneo Saga, Yuji Watanabe, Yasutaka Kawamura, Mitsuru Koizumi, Junji Konishi, Kanji Torizuka and Robert C. Bast Jr.: "Development of a New Sensitive Immunoradiometric Assay for CA125: Mixed Use of Two Monoclonal Antibodies Reactive with Separate Epitopes." Journal of Tumor Marker Oncology 3: 65-71, 1988.
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「研究成果報告書概要(欧文)」より
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[Publications] Akira Matsumori, Tomoko Ohkusa, Yoshiki Matobe, Ikutaro Okada, Takehiko Yamada, Chuichi Kawai, Nagara Tamaki, Yuji Watanabe, Yoshiharu Yonekura, Keigo Endo, Junji Konishi, Ban-An Khaw and Edgar Haber: "Myocardial Uptake of Antimyosin Monoclonal Antibody in a Murine Model of Viral Myocarditis." Circulation 79: 400-405, 1989.
Description
「研究成果報告書概要(欧文)」より
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