Participation of Calcium Regulating Factors in Senile Dementia

1989 Fiscal Year Final Research Report Summary

• Project/Area Number: 63570505
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: OSAKA UNIVERSITY MEDICAL SCHOOL
• Principal Investigator: MORIMOTO Sigeto Osaka University Medical School, Department of Geriatic Medicine, Instructor, 医学部, 助手 (20150336)
• Co-Investigator(Kenkyū-buntansha): HIRONAKA Takashi Osaka University Medical School, Department of Geriatic Medicine, Fellow, 医学部附属病院, 医員
• Project Period (FY): 1988 – 1989
• Keywords: Senile dementia / Senile dementia of Alzheimer's type / Senile dementia of vascular type / Calcium / Parathyroid hormone / Calcitonin / 1,25-dihydroxyvitamin D

Research Abstract

Calcium-related factors were compared in 60 elderly female subjects, who were classified into three groups as nondementia group (n=18), groups of senile dementia of Alzheimer type (SDAT, n=22) and of vascular type (VTD, n=20), The group of SDAT showed significant decrease in scrum calcium, and increases in serum parathyroid hormone and urinary Ca, and tendency of decrease in serum 1,25-dihydroxyvitamin D, compared to those of the nondementia group. However, the group of VTD, without showing these features, showed a tendency towards decreased scrum calcitonin. These results suggest that Ca and Ca-regulating hormones may play several important and different roles in senile dementia.

Research Products

• [Publications] 森本茂人,広中隆志,荻原俊男: "老年期痴呆とカルシウム代謝" 臨床科学. 24. 1270-1281 (1988)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 荻原俊男,森本茂人,真杉文紀,熊原雄一: "老年期痴呆と内分泌代謝異常" 臨床科学. 24. 1584-1588 (1988)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Ogihara T.,Miya K.,Morimoto S.: "Possible parficipation of calcium-regulating factors in senile dementia inelderly female subjects." Gerontology. (1990)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Masugi F.,Ogihara T.,Sakaguchi K.,Morimoto S.,et al.: "High plasma levels of cortisol in pationts with senile dementia of the Alzheimer's type." Methods and Finding in Experimental and Calinical Pharmacology. 11. 707-710 (1989)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Miya K.,Morimoto S.,Masugi F.,Ogihara T.,Hironaka T.,et al.: "Cognitive function and serum parathyroid hormone in elderly female subjects." Gerontology:East/West Cooperation.The Third Asia Oceania Regional Congress.Edited by Andrews S.Brolga Press,Curtin. 60-62 (1988)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Koh E.,Morimoto S.,Takamoto S.,Morita R.,Kim S.,Hironaka T.,Nabata T.,Ogihara T.: "Effect of valinomycin on calcium mobilization in vascular smooth cells induced by angiotensin II" Biochemical and Biophysical Research Communications.162. 191-497 (1989)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Imanaka S., Morimoto S., Onishi T., Takamoto S., Fukuo K., Koh E., Itoh K., Hironaka T., Shiraishi T., Morita R., Taniguchi K. and Kumahara Y.: "Effect of oestrogens on renal responsiveness to parathyroid hormone in elderly female subjects." Endocrinologia Japonica. 35(4). 593-599 (1988)
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• [Publications] Imanaka S., Morimoto S., Onishi T., Okada N., Kazuka T., Kitano Y., Yoshikawa K. and Kumahara Y.: "Comparison of 1, 25-dihydroxyvitamin D_3 receptor in fresh layers of epidermis and dermis from normal rat skin: separation of the epidermal sheet by despase treatment." Journal of Dermatology 15(4):299-303, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Itoh K., Morimoto S., Shiraishi T., Taniguchi K., Onishi T. and Kumahara Y.: "Increase of (Ca^<2+>+Mg^<2+>)-APTase activity of renal basolateral membrane by parathyroid hormone via cyclic AMP-dependent membrane phosphorylation." Biochemical and Biophysical Research Communications 150(1): 263-270 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Itoh K., Morimoto S., Shiraishi T., Taniguchi K., Onishi T. and Kumahara Y.: "Increase of (Ca^<2+>+Mg^<2+>)-ATpase activity of basolateral membranes by platelet-derived growth factor through a specific receptor." Biochemical and Biophysical Research Communications 153(6): 1315-1323, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Koh E., Morimoto S., Fukuo F., Itoh K., Hironaka T., Shiraishi T., Onishi T. and Kumahara Y.: "1, 25-Dihydroxyvitamin D_3 binds specifically to rat vascular smooth muscle cells and stimulates their proliferation in vitro." Life Sciences 42: 215-223, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Koh E., Morimoto S., Fukuo K., Morita R., Kim S., Onishi T. and Kumahara Y.: "1, 25-(OH)_2D_3 binds specifically to rat vascular smooth muscle cells and stimulates their proliferation in vitro." Vitamin D. Molecular, Cellular and Clinical Endocrinology. Edited by Norman AW, Schaefe K, Grigoleit H-G, v Hervath G. Walter de Gruyter, Berlin, New York. p372-373, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Miya K., Morimoto S., Masugi F., Ogihara T., Hironaka T., Shiraishi T., Fukuo K., Koh E., Itoh K., Yamamoto H., Imanaka S., Morita R., Taniguchi K. and Kumahara Y.: "Cognitive function and serum parathyroid hormone in elderly female subjects." Gerontology:East/West Co-oprtation Ptoceedi of the Third Regional Congress. Edited by Andrews G. Brolga Press, Curtin. P60-62, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Onishi T., Morimoto S., Yamamoto H., Takamot S., Fukuo K., Imanaka S., Hironaka T., Okada Y., Matoba R. and Kumahara Y.: "A patient with hypogonadotropic hypogonadism successfully treated by long-term pulsative administration of luteinizing hormone-releasing hormone." Endocrinologia Japonica, 35:892-898, 1988.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Fukuo K., Morimoto S., Kaji K., Koh E., Hironaka T., Shiraishi T., Itoh K., Onishi T. and Kumahara Y.: "Inhibitory effects of suramin on inductions by platelet-derived growth factor of mitogenisis and increase in cytosolic Ca^<2+> in chondrocytes." Cell Calcium. 10:29-35, 1989.
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• [Publications] Kim S., Morimoto S., Kawai Y., Koh E. and Ogihara T.: "Circulating levels of calcitonin gene-related peptides in patients with medullary thyroid carcinoma." Journal of Clinical Chemistry and Clinical Biochemistry. 27:423-427, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kim S., Morimoto S., Koh E., Miyashita Y. and Ogihara T.: "Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contracation." Biochemical and Biophysical Research Communications. 164:1003-1008, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Koh E., Morimoto S., Fukuo K., Morita R., Kim S., Hironaka T., Nabata T., Onishi T. and Ogihara T.: "Effects of valinomysin on calcium mobilization in vascular smooth muscle cells induced by angiotensin II." Biochemical and Biophysical Research Communications. 162:492-497, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kuroki T., Morimoto S. and Suda T.: "Actions of 1, 25-dihydroxyvitamin D_3 on normal, psoriatic and promoted epidermal keratinocytes." Endocrine, Metabolic and Immunologic Functions of Keratinocytes, Edited by Milstone L.M., Edelson R.L. Annals of the New York Academy of Sciences. P45-55, 19.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Masugi F., Ogihara T., Sakaguchi K., Otsuka A., Tsuchiya Y., Morimoto S., Kumahara Y., Saeki S. and Nishide M.: "High plasma levels of cortisol in patients with senile demintia of the Alzheimer's type." Methods and Findings in Experimental and Clinical Pharmacology 11: 707-710, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Morita R., Morimoto S., Koh E., Fukuo K., Kim S., Itoh K., Taniguchi K., Onishi T. and Ogihara T.: "Low density lipoprotein and apoprotein B induce increase in inositol trisphosphate and cytosolic free Ca^<2+> in vascular smooth muscle cells." Biochemistry International 18:647-653, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Shiraishi T., Morimoto S., Itoh K., Sato H., Sugihara K., Onishi T. and Ogihara T.: "Radioimmunoassay of human platelet-derived growth factor using monoclonal antibody toward its synthetic 73-97 fragment of B-chain." Clinica Chimica Acta 184: 65-74, 1989.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Koh E., Morimoto S., Nabata T., Kakamoto S., Kitano S. and Ogihara T.: "Effects of 1, 25-dihydroxyvitamin D_3 on the syntheses of DNA and glycosaminoglycans by rat aortic smooth muscle cells in vitro." Life Sciences 1990.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Morimoto S., Kim S., Fukuo K., Koh E., Morita R., Kitano S., Miyashita M., Imanaka S. and Ogihara T.: "Participation of both intracellular free Ca^<2+> and protein kinase C in tonic vasoconstriction induced by prostaglandin F_2alpha." European Journal of Pharmacology 1990.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Morimoto S., Koh E., Kim S., Fukuo K., Morita R. and Ogihara T.: "Effects of prostaglandin F_2alpha on the mobilization of cytosolic free calcium in vascular smooth muscle cells and on the tension of aortic strips from rats." American Journal of Hypertension 1990.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Ogihara T., Miya K. and Morimoto S.: "Possible participation of calcium-regulating factors in senile dementia in elderly female objects." Gerontology 1990.
  • Description: 「研究成果報告書概要(欧文)」より