1989 Fiscal Year Final Research Report Summary
The new classification of acute lymphocytic leukemia by cytoplasmiv antigen
| Project/Area Number |
63570566
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OKAWA Hiroji Tokyo Medical and Dental University, Department of Pediatrics, Medical Staff, 小児科, 助手 (90160431)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Shuji Tokyo Medical and Dental University, Department of Pediatrics, Medical Staff, 小児科, 助手 (20201593)
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| Project Period (FY) |
1988 – 1989
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| Keywords | T cell antigen / B cell antigen / Cytoplasmic immunoglobuline / cytoplasmic CD3 / T cell receptor / myelomonocytic antigen / pre-B cell / pre-T cell |
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| Research Abstract |
We examined the surface immunophenotype and the cytoplasmic CD3 or immunoglobulin in 163 cases of peroxidase negative lymphoproliferative disease. Po negative leukemic cells may be classified three major subclass such as T cell lineage type , B cell lineage type and non-T non-B cell type. Non-T non-B cell type consisted of myelomonocytic antigens (CD13,CD33) positive non lymphoid type and only HLA-DR antigen positive unclassified type.
According to the analysis of cytoplasmic and cell surface CD3, T cell lineage type is divided into three subclasses; pan T cell antigen positive and cytoplasmic CD3 negative precursor T cell type, cytoplasmic CD3 positive and surface CD3 negative pre- T cell type and surface CD3 positive T cell type. The surface immunophenotype of this pre-T cell was CD1(+), CD2(+), CD4(+) and CD8(+) which is compatible to Stage 2 of Reinherz' classification. This type showed also the rearrangement of TCR beta and did not show the rearrangement of IgH. B cell lineage type can also divided into three subclasses Precursor B cell is pan B cell antigens positive and cytoplasmic immunoglobulin negative cell. Pre B cell is cytoplasmic immunoglobulin positive and B cell is surface immunoglobulin positive. Pre B cell displaying heterogeneous from its surface antigens was homogeneous in cytoplasmic antigen.
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