Mechanism of the proliferation and chemotaxis of fibroblasts in wound healing

1991 Fiscal Year Final Research Report Summary

• Project/Area Number: 63570615
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kansai Medical University
• Principal Investigator: OGAWA Yutaka Kansai Medical University, Faculty of Medicine Professor, 医学部, 教授 (70026912)
• Co-Investigator(Kenkyū-buntansha): DOI Hideaki Kansai Medical University, Faculty of Medicine Assistant, 医学部, 助手 (10227689)
• Project Period (FY): 1988 – 1990
• Keywords: keloid / chemotaxis / testosterone / estradiol / lichen pilaris / fibloblast

Research Abstract

The chemotaxis of the fibroblasts was investigated using the human fibroblasts in the normal skin, keloid and hypertrophic scar.
The keloid-fibroblasts chemotaxis were promoted by testosterone, the other hand the hypertrophic scar-fibroblasts chemotaxis were promoted by estradiol significantly. The normal skin-fibroblasts didn't show a definite tendency for both hormones.
Clinically keloid revealed to be combined with lichen pilaris in high frequency. 42 of 67 (62.8 %) keloid-patients seen at Kansai Medical University from 1987 to 1990 showed a coexistence with lichen pilaris.
The other hand, non-keloid comparisons showed only 1.1% (5 of 451) with lichen pilaris.
This suggests that the hair-related disorder may be related to the etiological factor of keloid formation.