1989 Fiscal Year Final Research Report Summary
THE ROLE OF PITUITARY DESENSITIZATION IN THE ETIOLOGY OF AMENORRHEA
| Project/Area Number |
63570768
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | GUNMA UNIVERSITY |
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Principal Investigator |
MIZUNUMA Hideki GUNMA UNIVERSITY DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (10125875)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Pituitary desensitization / Amenorrhea / PCO / pulsatile LH-RH administration / LH-RHパルス療法 |
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| Research Abstract |
In order to analyze the role of pituitary desensitization in the etiology of amenorrhea, LH pulse frequency and pituitary response to LH-RH test were evaluated. The mean LH pulse frequency of women with negative gestagen test was less than that of normal cycling women and the response to LH-RH test showed positive correlation with LH pulse frequency, suggesting that lack of LH-RH secretion from the hypothalamus is the main cause of this type of amenorrhea. On the other hand, women with PCO had high LH pulse frequency and augmented LH response to LH-RH, but there is negative correlation between LH pulse frequency and response to LH-RH. These results indicate that the pituitary of PCO patient is being desensitized but still can afford to release LH in response to LH-RH. Of patients with hypothalamic amenorrhea and with positive gestagen test. women accompanied with obesity had high LH pulse frequency but impaired response to LH-RH test, indicating that the pituitary of these women has been desensitized by endogenous LH-RH release. Synthetic LH-RH was administered in a pulsatile manner to these women in order to induce ovulation by using the infusion pump. Women with low LH pulse frequency showed good response to this pulsatile LH-RH administration, while women whose pituitary had been desensitized had no response. In the meanwhile, women with PCO showed good response to this in the first treatment cycle, but from the second cycle the response was poor, suggesting that the pituitary became refractory. Thus present results clearly demonstrate the role of pituitary desensitization in the etiology of amenorrhea and the analysis of the desensitization is quite important to evaluate hypothalamo-pituitary function of patients with amenorrhea.
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