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1990 Fiscal Year Final Research Report Summary

Pathophysiology of Preeclampsia : The Role of Microcirculation

Research Project

Project/Area Number 63570787
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKyushu University

Principal Investigator

MAEDA Hirotaka  Kyushu University, Faculty of Medicine, Research Associate, 医学部, 助手 (20199631)

Co-Investigator(Kenkyū-buntansha) SAKAI Kazuhiro  Kyushu University, Faculty of Medicine, Research Associate, 医学部, 助手 (30221261)
MIYAMOTO Shingo  Kyushu University, Medical Institute of Bioregulation, Research Associate, 生体防御医学研究所, 助手 (40209945)
Project Period (FY) 1988 – 1990
KeywordsPreeclampsia / Microcirculation / Blood flow / Blood viscosity / Venous tone / Thermal conductivity / Endotheline / Endogenous factor
Research Abstract

From viewpoint of understanding the pathophysiology of preeclampsia, we attempted to assess the factors pertaining to change in tissue microcirculation.
In normal pregnancy, the following findings were obtained : 1) The increases in the number of venules and aggregation of blood flow in conjunctiva bulbi were noted with advance in gestation under conditions of the Intra Vital Video Microscopic System (IVVMS) observation, 2) the values of whole blood viscosity tended to decrease in the second trimester of pregnancy, 3) the peripheral venous tone was found to decrease in the third trimester of pregnancy. These findings suggest that the maternal circulation can adjust itself by controlling the microcirculation, in accord with the increase of bloo volume during normal course of pregnancy.
With regard to preeclamptic pregnancy, the findings were summarized as follows : 1) The decrease in thermal conductivity and disturbed vasodilatation was evident when studied after cooling in the skin and subcutaneous tissues, by means of the equipment measuring deep body temperature distribution, 2) The decrease in the number of venules and the increase of sludge of blood flow measured using IVVMS were observed, 3) the increase in the value of whole blood viscosity together with increase in the peripheral venous tone were noted when compared with those in normal pregnancy. These findings indicate that the disturbance in the tissue microcirculation and the disturbance of both vasodilatation and venodilatation were the determinant factors characterizing the pathophysiological changes in preeclamptic women.
From the study on cell-biology, it was found that there exist the endogeneous factors in the serum of preeclamptic women, thereby making strong cytotoxic effect on endothelial cells.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Miyamoto S: "Circadian rhythm of plasma atrial natriuretic peptide,aldosterone and blood pressure during the third trimester in normal and preeclamptic pregnancies" American Journal of Obstetrics and Gynecology. 158. 361-365 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto S: "How does preeclampsia influence thermal conductivity of the skin?" International Journal of Gynecology and Obstetrics. 26. 361-365 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto S: "Characteristics of changes in blood circulation induced by cold stimulation in preーeclamptic women." International Journal of Gynecology and Obstetrics. 27. 159-165 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto S: "Physiologic role of endogenous human atrial natriuretic peptide in preeclamptic pregnancies" American Journal of Obstetrics and Gynecology. 160. 155-159 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto S: "A possible explanation for nocternal hypertension preーeclamptics." Clinical and Experimental Hypertension In Pregnancy B. 3. 495-506 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sumioki H: "Circadian variations of plasma atrial natriuretic peptide in four types of hypertensive disorder during pregnancy." British Journal of Obstetrics and Gynaecology. 96. 922-927 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsukimori K: "Circadian variations of plasma colloid osmotic pressure during the third trimester in normal and preeclamptic pregnancies." Clinical and Experimental Hypertension In Pregnancy B. 8. 331-342 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai K: "The effect of normal pregnancy and pregnancy induced hypertension on peripheral venous tone." Acta Volume of VII World Congress of Hypertension In Pregnancy.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Miyamoto: "Circadian rhythm of plasma atrial natriuretic peptide, aldosterone and blood pressure during the third trimester in normal and pre-eclamptic pregnancies." Am. J. Obstet. Gynecol.158. 361-365 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Miyamoto: "How does pre-eclampsia influence thermal conductivity of the skin?" Int. J. Gynecol. Obstet.26. 361-365 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Miyamoto: "Characteristics of changes in blood circulation induced by cold stimulation in pre-eclamptic women." Int. J. Gynecol. Obstet. 27. 159-165 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Miyamoto: "Physiologic role of endogenous human atrial natriuretic peptide in pre-eclamptic pregnancies." Am. J. Obstet. Gynecol.160. 155-159 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Miyamoto: "A possible explanation for nocternal hypertension in preeclamptics." Clin. and Exper. Hyper. In Pregnancy B. 3. 495-506 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Sumioki: "Circadian variations of plasma atrial natriuretic peptide in four types of hypertensive disorder during pregnancy." Brit. J. Obstet. Gynaecol.96. 922-927 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Tsukimori: "Circadian variations of plasma colloid osmotic pressure during the third trimester in normal and preeclamptic pregnancies." Clin. and Exper. Hyper. In Pregnancy B. 8. 331-342 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Sakai: "The effect of normal pregnancy and pregnancy induced hyper on peripheral venous tone." Acta Volume of Z World Congress of Hypertension in Pregnancy.(1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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