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1989 Fiscal Year Final Research Report Summary

Trial manufacture of visual field specific stimulator by means of computer image frame memory and an application to brain metabolic mapping.

Research Project

Project/Area Number 63870007
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionUniversity of Tokyo, Faculty of Medicine

Principal Investigator

MIYASHITA Yasushi  Faculty of Medicine, Department of Phygiology, Professor, 医学部(医), 教授 (40114673)

Project Period (FY) 1988 – 1989
KeywordsVisual memory / Visual stimuli / Image frame memory / Brain metabolism / 2-deoxyglucose method / Cerebral temporal cortex / Cerebellar flocculus
Research Abstract

We obtained two major results in this research project; first was to manufacture a visual stimulator and to show its effectiveness in an electrophysiological single-unit recording. Second was to apply it to the metabolic mapping of the brain.
We had already shown merits of using "fractal patterns" in the research of visual memory. In this project our visual stimulator was constructed by modifying the FBX24 (Texnai) image frame memory system. The stimulator utilized the zoom, pan and scroll functions of FBX24 and succeeded in generating fractal patterns and presenting them at any position of the visual field in any size within 17msec. By using this stimulator we found that a shape-selective neural activity in the temporal cortex was highly selective for the pictorial information and was independent of the physical attributes such as size, orientation, color or position of the presented stimulus. In the hippocampus we found neuronal activity related to the place in which a stimulus was shown. This finding supports the hypothesis that the hippocampus contributes to the place memory. In the second application to metabolic mapping of the brain, local glucose utilization rates (LGU) were measured by 2-deoxyglucose autoradiography method after unilateral visual stimulation. We found that the cerebellar flocculus, especially in the contralateral side, exhibited high LGU during the visual stimulation. In the middle one-third of the contralateral flocculus we found patch-like high LGU areas, which may correspond to the cerebellar microzones.
In 1989 a positron emission tomography (PET) was introduced in the Tokyo University Hospital and the Department of Radiology asked us to modify our visual stimulator for the PET system. It is important to further develop our results for a clinical diagnosis.

  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Y.Miyashita: "Neuronal correlate of pictorial short-term memory in the primate temporal cortex" Nature. 331. 68-70 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Mori: "Metabolic responses of the flocculus to optokinetic stimuli as revealed by the[^<14>C]2-deoxyglucose method in pigmented rats." Neuroscience Research. 5. 258-264 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] P.M.B.Cahusac: "Hippocampal activity related to the processing of single sensory-motor associations" Neuroscience Lett.90. 265-272 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Miyashita: "Neuronal representation of pictorial working memory in the primate temporal cortex" Dynamic interaction in Neural Networks(eds.Arbib,M.A.& Amari,S.),Springer-Verlag,New York. 183-191 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Miyashita: "Cerebellar mechanisms in the adaptation of vestibulo-ocular reflex." Dynamic interaction in Neural Networks(eds.Arbib,M.A.& Amari,S.)Springer-Verlag,New York. 227-237 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Miyashita: "Neuronal correlate of visual associative long-term memory in the primate temporal cortex." Nature. 335. 817-820 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Mori: "Localized metabolic responses to optokinetic stimulation in the brain stem nuclei and the cerebellum investigated with the[^<14>C]2-deoxyglucose method in rats." Neuroscience(IBRO). 30. 271-281 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.T.Rolls: "Hippocampal neurons in the monkey with activity related to the place in which a stimulus is shown." J.Neuroscience. 9. 1835-1845 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Miyashita: "How is the visual associative memory represented in neurons of the primate temporal cortex?" Neural Programming(ed.M.Ito)Karger. 149-161 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] P.M.B.Cahusac: "Responses of hippocampal formation neurons in the monkey related to delayed spatial response and object-place memory tasks" Behav.Brain Res.33. 229-240 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Miyashita: "Representation of pictorial associative memory in neurons of the primate temporal" Biomed.Res.10,suppl.2. 99-105 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "図形概念を記憶する側頭葉ニュ-ロン群" 科学. 58. 403-404 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "視覚再認記憶のニュ-ロン機構" 神経研究の進歩. 32. 553-565 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "記憶のメカニズム" 脳の科学(伊藤正男・桑原武夫編 同文書院). 205-222 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "視覚記憶のメカニズム" ブレインサイエンスI(佐藤昌康編 朝倉書店. 39-53 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "〈知能〉の破片" 理想. 640. 25-36 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "記憶のメカニズム--認知神経科学の試み" 認識し行動する脳(伊藤正男・佐伯編 東京大学出版会). 211-237 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤正男: "記憶" 現代精神医学大系. 88-b. 217-242 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "記憶・学習の神経機構" 脳のメカニズム(第3回「大学と科学」公開シンポジウム組織委員会編). 132-144 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下保司: "大脳のメモリ-ニュ-ロン" 生体の科学. 40. 121-126 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Miyashita: "Neuronal correlate of pictorial short-term memory in the primate temporal cortex." Nature, 331, 68-70, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Mori: "Metabolic responses of the flocculus to optokinetic stimuli as revealed by the [^<14>C]2-deoxyglucose method in pigmented rats." Neuroscience Research, 5, 258-264, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] P.M.B. Cahusac: "Hippocampal activity related to the processing of single sensory-motor associations." Neuroscience Lett., 90, 265-272, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Miyashita: "Neuronal representation of pictorial working memory in the primate temporal cortex." Dynamic Interactions in Neural Networks (eds. Arbib, M.A. & Amari, S.), Springer-Verlag, New York, pp.183-191, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Miyashita: "Cerebellar mechanisms in the adaptation of vestibuloocular reflex." Dynamic Interactions in Neural Networks (eds. Arbib, M.A. & Amari, S.), Springer-Verlag, New York, pp.227-237, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Miyashita: "Neuronal correlate of visual associative long-term memory in the primate temporal cortex." Nature, 335, 817-820, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Mori: "Localized metabolic responses to optokinetic stimulation in the brain stemnuclei and the cerebellum investigated with the [^<14>C]2-deoxyglucose method in rats." Neuroscience(IBRO), 30, 271-281, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.T. Rolls: "Hippocampal neurons in the monkey with activity related to the place in which a stimulus is shown." J. Neuroscience, 9, 1835-1845, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Miyashita: "How is the visual associative memory represented in neurons of the primate temporal cortex?" Neural Programming(ed. M. Ito), 149-161, Karger, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] P.M.B. Cahusac: "Responses of hippocampal formation neurons in the monkey related to be laid partial response and object-place memory tasks." Behav. Brain Res., 33, 229-240, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Miyashita: "Representation of pictorial associative memory in neurons of the primate temporal." Biomed. Res., 10, suppl. 2, 99-105, 1989.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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