1989 Fiscal Year Final Research Report Summary
Intra-cellular manipulation of human retroviruses by NOS
| Project/Area Number |
63870022
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
HATANAKA Masakazu Institute for Virus Research Kyoto University Professor, ウイルス研究所, 教授 (30142300)
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| Co-Investigator(Kenkyū-buntansha) |
MAKI Masatoshi Institute for Virus Research Kyoto University Instructor, ウイルス研究所, 助手 (40183610)
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| Project Period (FY) |
1988 – 1989
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| Keywords | NOS / Human retrovirus / HTLV-I / HIV-I / Nucleolar targeting / Messenger RNA / Intra-cellular manipulation / HIV-I |
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| Research Abstract |
We discovered the nucleolar targeting signal (NOS) in human retroviruses, HTLV-I and HIV-I. The NOS consists of peptides with 9-19 amino acid residues, of which the existence leads proteins to accumulate in the nucleoli of cells. The loss of the signal function coincides with the loss of regulatory functions of human retroviruses. such intracellular manipulation of human retroviruses by NOS may provide a new method to prevent the onset of human retroviral diseases.
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