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1990 Fiscal Year Final Research Report Summary

Development of Multifunctional Liquid-Liquid Oxygenator

Research Project

Project/Area Number 63870053
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionInstitute for Medical & Dental Engineering, Tokyo Medical & Dental University

Principal Investigator

TSUJI Takayuki  Tokyo Medical & Dental University Institute for Medical & Dental Engineering, Associate professor, 医用器材研究所, 助教授 (00075764)

Co-Investigator(Kenkyū-buntansha) SUMA Kozo  Tokyo Women's Medical College, 2nd Hospital, Professor, 教授 (00075186)
SAITO Hirokazu  Tokyo Medical & Dental University Institute for Medical & Dental Engineering, Te, 教務職員 (00205668)
TAMURA Toshiyo  Tokyo Medical & Dental University, Institute for Medical & Dental Engineering, R, 助手 (10142259)
TOYOSHIMA Takeshi  Tokyo Medical & Dental University, Institute for Medical & Dental Engineering, R, 助手 (40014146)
TOGAWA Tatsuo  Tokyo Medical & Dental University, Institute for Medical & Dental Engineering, P, 教授 (40013859)
Project Period (FY) 1988 – 1990
KeywordsECMO / EVA hollow fiber / Hyperbaric liquid-liquid oxygenator / Multifunctional oxygenator / 差圧自動制御装置
Research Abstract

Hyperbaric liquid-liquid oxygenator made of ethylene vinyl alcohol copolymer (EVA) hollow fiber was developed in which gas exchange took place between venous blood and oxygen carrier solution such as saline, dialysate, or artificial blood (FC43). Oxygen carrier solution was saturated in the air-tight circuit with hyperbaric (up to 1.0 atm added) pure oxygen across the EVA membrane which is known to need small amount of heparin in use for hemodialysis. High pressure (Ps) was controlled with a pressure regulator, and oxygen flow rate, by a mass flowmeter. Solution at 37^゚C shifted at the rate of 0.94ml/min per at the transmembrane pressure of 10 mmHg in the oxygenator (0.8m^2) into the blood circuit. Shifted solution into the blood circuit was ultrafiltrated with a dialyzer interposed in the downstream circuit and recirculated to the pressurized circuit.
This system working not only as an oxygenator but also as a hemodialyzer with small amount of heparin and without plasma leakage is suitable for ECMO for a neonate.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 辻 隆之: "高圧気相型ホロ-ファイバ人工肺システムのin vitro実験による検討" 人工臓器. 19. 476-479 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "エチレンビニ-ルアルコ-ル共重合体ホロ-ファイバ液相型人工肺による長期呼吸補助システムの開発に関する実験的研究" エル・エス・ティ学会誌. 3. 20-26 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "高圧多機能型人工肺システムの開発" 医器学. 60. 29-33 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "人工肺の動物実験による評価" アニテックス. 2. 154-157 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "液相型EVA人工肺差圧制御システムの開発" 医器学. 61. 53-57 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "高圧気液両相型キャピラリ人工肺における酸素ガス移動の解析" 人工臓器.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "医用材科,「医療を支える先端技術」" 第3回「大学と科学」公開シンポジウム組織委員会, 361 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuji T, Togawa T, Tanishita K, Fukui Y, MUneoka K, Okamoto M, Sueoka A: "Development of ECMO system using an EVA hollow fiber liquid-type oxygenator" Jpn. J. Artif. Organs. 17 (3). 1240-1243 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Tanishita K, Takahashi M, Togawa T: "Development of the hyperbaric silastic hollow fiber oxygenator for ECMO" Jpn. J. Artif. Organs. 19 (1). 476-479 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Sueoka A, Toyoshima T, Tamura T, Saito H, Togawa T: "Development of the liquid-type ECMO oxygenator made of ethylene vinyl alcohol Copolymer fibers" Jlsts. 3 (1). 382-388 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Tanishita K, Takahashi M, Togawa T: "Development of hyperbaric multifunctional ECMO system with EVA hollow fiber oxygenator" Jjmi. 60 (1). 29-33 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Tanishita K, Takahashi M, Togawa T: "Hyperbaric dual mode ECMO system for patients with multiple organ failure" Proceedings of Fecmbe 1990. 94-95 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Sueoka A, Akasu H, Tanishita K, Saito H, Tamura T, Toyoshima T, Togawa T: "Development of an automatic pressure controller for the EVA liquid oxygenator" Jjmi. 61 (2). 53-57 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuji T, Tanishita K, Takahashi M, Togawa T: "Development of a multifunctional oxygenator made of EVA hollow fiber" Jpn. J. Artif. Organs. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanishita K, Tsuji T, Sekido A, Tatsuo Togawa: "Gas transfer in the oxygenator made of hollow fiber with three layered composite membrane" Jpn. J. Artif. Organs. (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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