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2017 Fiscal Year Annual Research Report

Radiogenomic diagnosis of brain tumors using artificial inteligence

Publicly Offered Research

Project AreaMultidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy
Project/Area Number 17H05308
Research InstitutionOsaka University

Principal Investigator

木下 学  大阪大学, 医学系研究科, 講師 (40448064)

Project Period (FY) 2017-04-01 – 2019-03-31
KeywordsRadiomics / 神経膠腫 / 脳腫瘍 / 人工知能
Outline of Annual Research Achievements

神経膠腫は中枢神経系に発生する希少がんで、手術・放射線治療・化学療法を組み合わせた集学的治療が実施されているが、予後不良な疾患である。神経膠腫は分子生物学的には数種類の異なった機序で発症していることが明らかになってきており、分子生物学的手法を用いた新たな病態理解・診断・治療のアプローチが求められている。
腫瘍の分子情報の取得には腫瘍組織の採取が必須であり、脳腫瘍の場合には開頭術という侵襲的な手技を経由する必要がある。このような侵襲的な手技を回避すべく、radiogenomicsもしくは人工知能という新規技術を発展させて、放射線画像という非侵襲的な診断技術で腫瘍の分子情報の取得を試みようとするのが本研究の主たる目的であった。
本研究によって、放射線画像から神経膠腫の主たる遺伝子変異(特にIDH遺伝子変異)を高精度で診断する(正診率80%以上)技術開発が成功した。さらに、放射線画像解析に人工知能支援を導入することで、従来のRadiomics法と比較して、診断精度の向上が見込まれることも明らかにすることができた。
脳腫瘍に限らず、本研究手法が大規模臨床試験など臨床医学における大規模データを網羅的に解析し、従来型の解析では明らかにすることが出来なかった「画像」と腫瘍の「分子生物学」の関係性を明らかにでき、ビッグデータの活用、解析が推進されている昨今、全身疾病の「画像」と「分子情報」の統合解析を推し進める上で極めて重要な知見を得ることができた。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

平成29年10月、本研究と研究内容が近いデープ ラーニング(機械学習アルゴリズムの一種)を 用いた脳腫瘍の画像分子遺伝学診断技術開発に 関する研究成果が、他の研究グループより発表 された。本研究遂行上、当該成果を踏まえてRadiogenomicsを再検討・再設計する必要が生じたものの、当初の研究目的を概ね達成している。

Strategy for Future Research Activity

本研究課題が目的としていた、人工知能支援下での神経膠腫におけるRadiogenomics研究は当初の研究計画通り遂行された。しかしながら、主たる遺伝子変異であるIDH変異を持ってしても、その推定精度は85%程度に留まっており、実臨床での実装を考えると、改善の余地を残している。
今後の研究方向としては人工知能が「誤診断」した理由の一つ一つを明らかにし、人工知能が「不得手」とする症例の洗い出しを行いつつ、診断アルゴリズムの改善を行っていくことがある。
また、本研究アプローチが神経膠腫に対していは有用であることが明らかとなったが、他の中枢神経系疾患への技術応用・転用も積極的に検討していく必要がある。

  • Research Products

    (20 results)

All 2019 2018 2017

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma2019

    • Author(s)
      Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 142 Pages: 241~251

    • DOI

      10.1007/s11060-019-03113-2

    • Peer Reviewed
  • [Journal Article] Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors2019

    • Author(s)
      Sonoda Yukihiko、The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology、Yokoo Hideaki、Tanaka Shinya、Kinoshita Manabu、Nakada Mitsutoshi、Nishihara Hiroshi
    • Journal Title

      Brain Tumor Pathology

      Volume: in press Pages: in press

    • DOI

      10.1007/s10014-019-00337-y

    • Peer Reviewed
  • [Journal Article] Relationship between normalized distributional pattern and functional outcome in patients with acute cardiogenic cerebral embolism2019

    • Author(s)
      Takagaki Masatoshi、Kinoshita Manabu、Kawaguchi Atsushi、Murasawa Akira、Nakao Kazutami、Nakamura Hajime、Kishima Haruhiko
    • Journal Title

      PLOS ONE

      Volume: 14 Pages: NA

    • DOI

      10.1371/journal.pone.0210709

    • Peer Reviewed / Open Access
  • [Journal Article] Carotid artery stenting for patients with occipital vertebral anastomosis2018

    • Author(s)
      Kajikawa Ryuichiro、Fujinaka Toshiyuki、Nakamura Hajime、Kinoshita Manabu、Nishida Takeo、Kishima Haruhiko
    • Journal Title

      Interventional Neuroradiology

      Volume: 25 Pages: 212~218

    • DOI

      10.1177/1591019918802924

    • Peer Reviewed
  • [Journal Article] Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors2018

    • Author(s)
      Sasaki Takahiro、Fukai Junya、Kodama Yoshinori、et al
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 140 Pages: 329~339

    • DOI

      10.1007/s11060-018-2957-7

    • Peer Reviewed
  • [Journal Article] 11C-methionine-18F-FDG dual-PET-tracer based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy2018

    • Author(s)
      Hirata Takero、Kinoshita Manabu、Tamari Keisuke、Seo Yuji、Suzuki Osamu、Wakai Nobuhide、Achiha Takamune、Umehara Toru、Arita Hideyuki、Kagawa Naoki、Kanemura Yonehiro、Shimosegawa Eku、Hashimoto Naoya、Hatazawa Jun、Kishima Haruhiko、Teshima Teruki、Ogawa Kazuhiko
    • Journal Title

      Journal of Neurosurgery

      Volume: - Pages: 1~11

    • DOI

      10.3171/2018.4.JNS1859

    • Peer Reviewed
  • [Journal Article] Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas2018

    • Author(s)
      Arita Hideyuki、Kinoshita Manabu、et al
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: NA

    • DOI

      10.1038/s41598-018-30273-4

    • Peer Reviewed / Open Access
  • [Journal Article] Stereotactic image based histological analysis reveals a correlation between 11C methionine uptake and MGMT promoter methylation in non enhancing gliomas2018

    • Author(s)
      Okita Yoshiko、Shofuda Tomoko、Kanematsu Daisuke、Yoshioka Ema、Kodama Yoshinori、Mano Masayuki、Kinoshita Manabu、Nonaka Masahiro、Nakajima Shin、Fujinaka Toshiyuki、Kanemura Yonehiro
    • Journal Title

      Oncology Letters

      Volume: NA Pages: NA

    • DOI

      10.3892/ol.2018.8866

    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial2018

    • Author(s)
      Kayama Takamasa、Sato Shinya、Sakurada Kaori、et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 36 Pages: 3282~3289

    • DOI

      10.1200/JCO.2018.78.6186

    • Peer Reviewed / Open Access
  • [Journal Article] Enlargement of papillary glioneuronal tumor in an adult after a follow-up period of 10 years: a case report2018

    • Author(s)
      Fujita Yuya、Kinoshita Manabu、Ozaki Tomohiko、Kitamura Masanori、Nakatsuka Shin-ichi、Kanemura Yonehiro、Kishima Haruhiko
    • Journal Title

      Journal of Surgical Case Reports

      Volume: 2018 Pages: NA

    • DOI

      10.1093/jscr/rjy123

    • Peer Reviewed
  • [Journal Article] Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions2018

    • Author(s)
      Hirayama Ryuichi、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Kishima Haruhiko、Hashimoto Naoya、Fujimoto Yasunori、Yoshimine Toshiki
    • Journal Title

      Journal of Neurosurgery

      Volume: 128 Pages: 1707~1712

    • DOI

      10.3171/2017.3.JNS17169

    • Peer Reviewed
  • [Journal Article] Coil and Single-Stent Placement for Ruptured Dissecting Aneurysm of Middle Cerebral Artery: A Case Report2018

    • Author(s)
      Ozaki Tomohiko、Nishida Takeo、Fujita Yuya、Kishima Haruhiko、Kinoshita Manabu
    • Journal Title

      World Neurosurgery

      Volume: 113 Pages: 208~211

    • DOI

      10.1016/j.wneu.2018.02.117

    • Peer Reviewed
  • [Journal Article] Influence of region of interest designs on quantitative measurement of multimodal imaging of MR non enhancing gliomas2018

    • Author(s)
      Takano Koji、Kinoshita Manabu、Arita Hideyuki、Okita Yoshiko、Chiba Yasuyoshi、Kagawa Naoki、Watanabe Yoshiyuki、Shimosegawa Eku、Hatazawa Jun、Hashimoto Naoya、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Oncology Letters

      Volume: NA Pages: NA

    • DOI

      10.3892/ol.2018.8319

    • Peer Reviewed / Open Access
  • [Journal Article] Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography2017

    • Author(s)
      Izutsu Nobuyuki、Kinoshita Manabu、Yanagisawa Takufumi、Nakanishi Katsuhiko、Sakai Mio、Kishima Haruhiko
    • Journal Title

      World Neurosurgery

      Volume: 107 Pages: 1045.e5~1045.e8

    • DOI

      10.1016/j.wneu.2017.07.152

    • Peer Reviewed
  • [Journal Article] Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia2017

    • Author(s)
      Ozaki Tomohiko、Nakamura Hajime、Izutsu Nobuyuki、Masaie Hiroaki、Ishikawa Jun、Kinoshita Manabu
    • Journal Title

      Interventional Neuroradiology

      Volume: 23 Pages: 527~530

    • DOI

      10.1177/1591019917710810

    • Peer Reviewed
  • [Journal Article] Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis2017

    • Author(s)
      Verburg N.、Hoefnagels F.W.A.、Barkhof F.、Boellaard R.、Goldman S.、Guo J.、Heimans J.J.、Hoekstra O.S.、Jain R.、Kinoshita M.、Pouwels P.J.W.、Price S.J.、Reijneveld J.C.、Stadlbauer A.、Vandertop W.P.、Wesseling P.、Zwinderman A.H.、De Witt Hamer P.C.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 38 Pages: 1884~1891

    • DOI

      10.3174/ajnr.A5368

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Voxel-Based Lesion Mapping of Cryptogenic Stroke in Patients with Advanced Cancer: A Detailed Magnetic Resonance Imaging Analysis of Distribution Pattern2017

    • Author(s)
      Achiha Takamune、Takagaki Masatoshi、Oe Hiroshi、Sakai Mio、Matsui Hitoshi、Nakanishi Katsuhiko、Ozaki Tomohiko、Fujimoto Yasunori、Yoshimine Toshiki、Nakanishi Katsuyuki、Kinoshita Manabu
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Pages: 1521~1527

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.02.038

    • Peer Reviewed
  • [Presentation] Imapact of 11C-methionine/FDG dural tracer PET-based, compared with MRI-based target delination of malignant gliomas for radiation planning.2018

    • Author(s)
      Kinoshita M, Hirata T, Tamari K, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa
    • Organizer
      ociety for Neuro-onclogy (SNO) meeting
    • Int'l Joint Research
  • [Presentation] Radiogenomics of 154 WHO grade 2 and 3 gliomas via machine learning and the impact of texture analysis.2018

    • Author(s)
      Kinoshita M, Arita H, Kawaguchi A, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 26th Scientific Meeting 2018
    • Int'l Joint Research
  • [Presentation] Radionomic analysis of WHO grade 2 and 3 gliomas with genetic subgroup prediction.2017

    • Author(s)
      Kinoshita M, Arita H, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura K, Kanemura Y
    • Organizer
      Society for Neuro-onclogy (SNO) meeting.
    • Int'l Joint Research

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Published: 2019-12-27  

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