2018 Fiscal Year Annual Research Report
Hypothalamic control of hippocampal action selection
Publicly Offered Research
| Project Area | Mechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation |
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| Project/Area Number |
17H05591
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | decision making / hypothalamus / hippocampus / social behavior / spatial behavior |
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| Outline of Annual Research Achievements |
We have made great progress on this project. Using viral mediated circuit mapping, activity dependent cellular labeling, behavior and in vivo optogenetics and electrophysiology we have collected a comprehensive data set on the function of the SuM to hippocampal circuits. Our findings demonstrate the SuM can signal environmental novelty to the hippocampus. Unique about this signal is that the SuM can segregate and selectively route different types of information to the dentate gyrus (DG; context novelty) and CA2 (social novelty) for the modulation of mnemonic processing. This content-specific routing of novelty signals represents a new type of modulation of hippocampal processing. A manuscript detailing this findings is currently under peer review. In parallel we have used the efforts of this grant to help our published work demonstrating the application of up-conversion nanoparticles (UCNPs) as a method for minimally-invasive optogenetics (Chen et al, Science 2018).
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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