2021 Fiscal Year Annual Research Report
Multiscale understanding of social cognition in schizophrenia
Publicly Offered Research
| Project Area | Constructive understanding of multi-scale dynamism of neuropsychiatric disorders |
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| Project/Area Number |
21H00218
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | hippocampus / schizophrenia / CA2 / replay |
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| Outline of Annual Research Achievements |
Using chemogenetic manipulation and in vivo electrophyiological recording we discovered that transient inhibition of pyramidal cell activity in the CA2 region results in a loss of temporal and informational precision of hippocampal replay. We observed that with this manipulation often discrete memories were inappropriately reactivated at the same time, possibly reflecting the disordered thoughts in the schizophrenic brain and strengthening our hypothesis that CA2 is a key region to examine in this disorder. This work was published in 2021 in Neuron (He et al, doi: 10.1016/j.neuron.2021.08.034.) In addition we have established all the necessary behavioral paradigms and experimental techniques to extend these studies into social based behaviors. These include optogenetic approaches, viral stocks, and high density recording in mice performing social tasks.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We were pleased to published our first results in a good journal in FY2021; all experiments are progressing smoothly and all necessary behaviors and techniques are well established in the lab.
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| Strategy for Future Research Activity |
In FY2022 we will continue this line of research, conducting optogenetic manipulation of CA2 and SuM activity during social behaviors. Mice will be implanted with microdrives to record activity in the CA1 and CA2 regions of the hippocampus and analyzed to examine how social novelty changes the dynamic flow of informaition.
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