2022 Fiscal Year Annual Research Report
Circuit based genome editing for the treatment of stress related psychiatric disorders
Publicly Offered Research
| Project Area | Constructive understanding of multi-scale dynamism of neuropsychiatric disorders |
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| Project/Area Number |
21H00219
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
JOHANSEN JOSHUA 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (80625351)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | noradrenaline / brainstem / prefrontal / cell types |
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| Outline of Annual Research Achievements |
The locus coeruleus noradrenaline (LC-NA) system controls emotion and is implicated in psychiatric disorders. We've developed cell type specific molecular and circuit based perturbation and viral tracing approaches and and used them to study the role of the LC-NA system in aversive emotional learning and memory. In the last year we have finished tracing brain-wide afferent inputs to two projection defined LC-NA cell populations we've found to play opposing roles in aversive learning and extinction of aversive responding (Sulkes et al. 2023). In addition, we've identified opposing functional roles of distinct afferent inputs from prefrontal cortex in regulating fear extinction learning (Watanabe et al. in preparation). This work shows how LC-NA cell types are regulated by afferent inputs
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| Research Progress Status |
令和4年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和4年度が最終年度であるため、記入しない。
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