2023 Fiscal Year Annual Research Report
Optimal wound healing in a hybrid mechanochemical model
Publicly Offered Research
| Project Area | Information physics of living matters |
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| Project/Area Number |
22H04841
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Schnyder Simon 東京大学, 生産技術研究所, 特任助教 (50812616)
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | optimal control / collective behavior |
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| Outline of Annual Research Achievements |
I set out to study how wound healing can be interpreted as a process of collective behavior which has evolved to be optimal, as in optimizing a utility function.
However, it became necessary to study the control theoretic approach of the project in a more contained situation and I identified the study of epidemics as a suitable target, both for its general importance as a subject and its reduced simulation complexity as compared to a full tissue simulation.
In two studies, we studied social distancing behavior of populations as it arises from individuals optimizing their own decisions, balancing infection costs with the costs of avoiding contacts with others, e.g. worsening their economic situation or psychological health. We studied how social distancing is affected by the expectation of a vaccination: People social distance more strongly the earlier they expect a vaccine to arrive and the more certain they are about its early arrival time. We also showed how social distancing is affected by limited capacity in the healthcare system. Finally, we demonstrated how governments can design incentives to help individuals make optimal decisions.
I hope that these findings will affect how governments communicate about the state of an epidemic, vaccination development, and that it will help design better government interventions in future epidemics. I hope that this will also transfer into additional understanding of optimal collective behavior in other systems such as cellular tissues.
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| Research Progress Status |
令和5年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和5年度が最終年度であるため、記入しない。
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