2023 Fiscal Year Annual Research Report
Development of SpiroBipyridine Ligands for Efficient and Selective C-H Activation
Publicly Offered Research
| Project Area | Digitalization-driven Transformative Organic Synthesis (Digi-TOS) |
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| Project/Area Number |
22H05384
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
イリエシュ ラウレアン 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー (40569951)
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| Project Period (FY) |
2022-06-16 – 2024-03-31
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| Keywords | organic synthesis |
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| Outline of Annual Research Achievements |
The purpose of this research is the development of new spirobipyridine ligands and of reaction conditions for the efficient and site-selective catalytic functionalization of arenes. During FY2023, we performed a mechanistic study by computations and an unprecedented ligand kinetic isotope effect to prove that a noncovalent interaction between a C-H bond of the spirobipyridine ligand's backbone and the pi electrons of the arene substrate can accelerate the iridium-catalyzed activation of arenes.
We also developed spirobipyridine ligands bearing hydroxyl (OH) groups capable of recognizing pyridine substrates through hydrogen bonding, and both accelerate and control the site selectivity in iridium-catalyzed borylation.
Finally, we developed a spirobipyridine ligand that enables meta-selective iridium-catalyzed silylation of monosubstituted arenes.
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| Research Progress Status |
令和5年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和5年度が最終年度であるため、記入しない。
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