2014 Fiscal Year Annual Research Report
Identifying a microendophenotype of post-traumatic stress disorder
Publicly Offered Research
| Project Area | Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels. |
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| Project/Area Number |
25116531
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
JOHANSEN JOSHUA 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (80625351)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | fear / prediction error / periaqueductal gray / subregion specificity |
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| Outline of Annual Research Achievements |
We have made continued progress in Heisei 26 on delineating a circuit mechanism for setting fear learning levels. Following up on our previous work from Heisei, we have discovered that central nucleus of the amygdala (CeA) inputs to the periaqueductal gray (PAG) regulates prediction error neural coding and memory strength through differential modulation of distinct subregions of the PAG.Specifically we found that optogenetic inhibition of CE inputs to ventrolateral PAG (vlPAG) inhibited auditory conditioned stimulus (CS) processing in vlPAG without affecting shock unconditioned stimulus (US) processing.In contrast, the same optogenetic manipulation disinhibited shock US processing, but had no effect on CS processing in dorsolateral PAG neurons.
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| Research Progress Status |
26年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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[Journal Article] Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation2014
Author(s)
Johansen, J.P., Diaz-Mataix, L., Hamanaka, H. Ozawa, T., Ycu, E., Koivumaa, J., Kumar, A., Hou, M., Deisseroth, K., Boyden, E. & LeDoux, J.E.
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 111(51)
Pages: E5584-92
Peer Reviewed / Open Access / Acknowledgement Compliant
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