2015 Fiscal Year Annual Research Report

Novel Chiral Bifunctional Heterogeneous Catalysts for Asymmetric Tandem Reactions

Publicly Offered Research

Project Area	Advanced Molecular Transformations by Organocatalysts
Project/Area Number	26105711
Research Institution	The University of Tokyo
Principal Investigator	ユーウージン東京大学, 理学(系)研究科(研究院), 助教 (70626077)
Project Period (FY)	2014-04-01 – 2016-03-31
Keywords	heterogeneous catalysis / organocatalysis / asymmetric catalysis / aerobic oxidation
Outline of Annual Research Achievements	Over the fiscal year, we have been investigating the fabrication of a chiral heterogeneous bifunctional catalyst that is capable of performing an asymmetric tandem oxidation process (TOP). We were able to combine gold/palladium nanoparticles (NPs) with a polymer-supported chiral phosphoric acid (CPA) catalyst, and this composite material possessed the capacity to catalyze the sequential aerobic oxidation-asymmetric aza-Friedel Crafts reaction. We were able to perform this asymmetric TOP to obtain various chiral piperazines in high yields and enantioselectivites. In addition, we were able to recover and reuse the heterogeneous several times without significant loss in yields and enantioselectivites.
Research Progress Status	27年度が最終年度であるため、記入しない。
Strategy for Future Research Activity	27年度が最終年度であるため、記入しない。

(2 results)