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2022 Fiscal Year Annual Research Report

細胞機能を司るオルガネラ・ゾーンの解読

Compiling the Research Achievements

Project AreaToward an integrative understanding of functional zones in organelles
Project/Area Number 22H04899
Research InstitutionTokyo Medical and Dental University

Principal Investigator

清水 重臣  東京医科歯科大学, 難治疾患研究所, 教授 (70271020)

Project Period (FY) 2022-04-01 – 2023-03-31
Keywordsオルガネラ / ミトコンドリア / ゴルジ体 / 小胞体
Outline of Annual Research Achievements

オルガネラ・ゾーン研究を継続する上で、研究者間の連携を維持すること、情報交換を行うことを目的に、オルガネラゾーンセミナーを毎月オンラインで開催し、2023年3月までに通算21回のオンラインセミナーを開催した。これを基盤として、領域内外の研究者との議論、情報の相互交換、共同研究の推進を図ることができた。
また、新型コロナ感染症の影響で前年度に開催できなかった国際シンポジウムを立教大学において開催し、オルガネラ研究の第一人者であるPietro De Camilli教授、Alissa M Weaver教授、Jaakko Saraste教授、Byung Il Lee教授、Fabien Alpy教授を含めて、約100名の国内外の研究者が参加した。同シンポジウムでは、招聘した教授からの講演を聴取するとともに、最新のオルガネラ解析技術などに関する意見交換を行い、共同研究を打ち合わせた。
さらに、各計画班、公募班の先生方からの情報提供を受けて、5年間の領域の研究を総括を行うとともに、事後評価報告書の作成を行なった。また、報告書に対するフィードバックを行い、オルガネラゾーン研究の更なる研究の進捗を図った。

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

  • Research Products

    (25 results)

All 2023 2022 Other

All Int'l Joint Research (3 results) Journal Article (19 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Penn State University/Washington University/Harvard University(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      Penn State University/Washington University/Harvard University
  • [Int'l Joint Research] Yonsei University(韓国)

    • Country Name
      KOREA (REP. OF KOREA)
    • Counterpart Institution
      Yonsei University
  • [Int'l Joint Research] Barcelona University(スペイン)

    • Country Name
      SPAIN
    • Counterpart Institution
      Barcelona University
  • [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice2022

    • Author(s)
      Matsuda Hiroki、Nibe-Shirakihara Yoichi、Tamura Akiko、Aonuma Emi、Arakawa Satoko、Otsubo Kana、Nemoto Yasuhiro、Nagaishi Takashi、Tsuchiya Kiichiro、Shimizu Shigeomi、Ma Averil、Watanabe Mamoru、Uo Motohiro、Okamoto Ryuichi、Oshima Shigeru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 592 Pages: 74~80

    • DOI

      10.1016/j.bbrc.2021.12.111

  • [Journal Article] Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression2022

    • Author(s)
      Yanagi Tomoki、Kikuchi Hiroaki、Susa Koichiro、Takahashi Naohiro、Bamba Hiroki、Suzuki Takefumi、Nakano Yuta、Fujiki Tamami、Mori Yutaro、Ando Fumiaki、Mandai Shintaro、Mori Takayasu、Takeuchi Koh、Honda Shinya、Torii Satoru、Shimizu Shigeomi、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
    • Journal Title

      Genes to Cells

      Volume: 28 Pages: 5~14

    • DOI

      10.1111/gtc.12989

  • [Journal Article] FLIP-based autophagy-detecting technique reveals closed autophagic compartments2022

    • Author(s)
      Sakurai Hajime Tajima、Arakawa Satoko、Noguchi Saori、Shimizu Shigeomi
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: 5721

    • DOI

      10.1038/s41598-022-26430-5

  • [Journal Article] Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction2022

    • Author(s)
      Matsui Yudai、Takemura Naoki、Shirasaki Yoshitaka、Takahama Michihiro、Noguchi Yoshihiko、Ikoma Kenta、Pan Yixi、Nishida Shuhei、Taura Manabu、Nakayama Akiyoshi、Funatsu Takashi、Misawa Takuma、Harada Yoshie、Sunazuka Toshiaki、Saitoh Tatsuya
    • Journal Title

      International Immunology

      Volume: 34 Pages: 505~518

    • DOI

      10.1093/intimm/dxac028

  • [Journal Article] Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung2022

    • Author(s)
      Ikoma Kenta、Takahama Michihiro、Kimishima Atsushi、Pan Yixi、Taura Manabu、Nakayama Akiyoshi、Arai Masayoshi、Takemura Naoki、Saitoh Tatsuya
    • Journal Title

      International Immunology

      Volume: 34 Pages: 493~504

    • DOI

      10.1093/intimm/dxac018

  • [Journal Article] Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection2022

    • Author(s)
      Liu Chun-chun、Liu Ya-yun、Zhou Jiang-fei、Chen Xi、Chen Huan、Hu Jia-huan、Chen Jing、Zhang Jin、Sun Rui-cong、Wei Jian-chao、Go Yun Young、Morita Eiji、Zhou Bin
    • Journal Title

      PLOS Pathogens

      Volume: 18 Pages: e1010294

    • DOI

      10.1371/journal.ppat.1010294

  • [Journal Article] Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System2022

    • Author(s)
      Kamikawa Yasunao、Saito Atsushi、Imaizumi Kazunori
    • Journal Title

      Neurochemical Research

      Volume: 47 Pages: 2478~2487

    • DOI

      10.1007/s11064-022-03608-x

  • [Journal Article] Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide2022

    • Author(s)
      Goto Asako、Sakai Shota、Mizuike Aya、Yamaji Toshiyuki、Hanada Kentaro
    • Journal Title

      iScience

      Volume: 25 Pages: 104624~104624

    • DOI

      10.1016/j.isci.2022.104624

  • [Journal Article] Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum2022

    • Author(s)
      Shimasaki Kentaro、Kumagai Keigo、Sakai Shota、Yamaji Toshiyuki、Hanada Kentaro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Pages: 4025~4025

    • DOI

      10.3390/ijms23074025

  • [Journal Article] Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling2022

    • Author(s)
      Moriyama Hidenori,Endo Jin,Kataoka Masaharu,Shimanaka Yuta,Kono Nozomu,Sugiura Yuki,Goto Shinichi,Kitakata Hiroki,Hiraide Takahiro,Yoshida Naohiro,Isobe Sarasa,Yamamoto Tsunehisa,Shirakawa Kohsuke,Anzai Atsushi,Katsumata Yoshinori,Suematsu Makoto,Kosaki Kenjiro,Fukuda Keiichi,Arai Hiroyuki,Sano Motoaki
    • Journal Title

      Nature Communications

      Volume: 13 Pages: 1234

    • DOI

      10.1038/s41467-022-30621-z

  • [Journal Article] Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 12022

    • Author(s)
      Maeda Fumio、Kato Akihisa、Takeshima Kosuke、Shibazaki Misato、Sato Ryota、Shibata Takuma、Miyake Kensuke、Kozuka-Hata Hiroko、Oyama Masaaki、Shimizu Eigo、Imoto Seiya、Miyano Satoru、Adachi Shungo、Natsume Tohru、Takeuchi Koh、Maruzuru Yuhei、Koyanagi Naoto、Jun Arii、Yasushi Kawaguchi
    • Journal Title

      Journal of Virology

      Volume: 96 Pages: 2301

    • DOI

      10.1128/jvi.00306-22

  • [Journal Article] Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers2022

    • Author(s)
      Soyama Hirotoshi、Nishio Miki、Otani Junji、Sakuma Toshiko、Takao Shintaro、Hara Shigeo、Masuda Takaaki、Mimori Koshi、Toyokuni Shinya、Lydon John P.、Nakao Kazuwa、Nishina Hiroshi、Fukumoto Takumi、Maehama Tomohiko、Suzuki Akira
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Pages: 265

    • DOI

      10.1073/pnas.2123134119

  • [Journal Article] Compartment-specific tuning of dendritic feature selectivity by intracellular Ca <sup>2+</sup> release2022

    • Author(s)
      O’Hare Justin K.、Gonzalez Kevin C.、Herrlinger Stephanie A.、Hirabayashi Yusuke、Hewitt Victoria L.、Blockus Heike、Szoboszlay Miklos、Rolotti Sebi V.、Geiller Tristan C.、Negrean Adrian、Chelur Vikas、Polleux Franck、Losonczy Attila
    • Journal Title

      Science

      Volume: 375 Pages: 382

    • DOI

      10.1126/science.abm1670

  • [Journal Article] GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER2022

    • Author(s)
      Matsumoto Shunsuke、Ono Suzuka、Shinoda Saori、Kakuta Chika、Okada Satoshi、Ito Takashi、Numata Tomoyuki、Endo Toshiya
    • Journal Title

      Journal of Cell Biology

      Volume: 221 Pages: 202

    • DOI

      10.1083/jcb.202104076

  • [Journal Article] Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites2022

    • Author(s)
      Rodriguez-Gallardo Sofia、Sabido-Bozo Susana、Ikeda Atsuko、Araki Misako、Okazaki Kouta、Nakano Miyako、Aguilera-Romero Auxiliadora、Cortes-Gomez Alejandro、Lopez Sergio、Waga Miho、Nakano Akihiko、Kurokawa Kazuo、Mu?iz Manuel、Funato Kouichi
    • Journal Title

      Cell Reports

      Volume: 39 Pages: 110768~110768

    • DOI

      10.1016/j.celrep.2022.110768

  • [Journal Article] The TGN/EE SNARE protein SYP61 and the ubiquitin ligase ATL31 cooperatively regulate plant responses to carbon/nitrogen conditions in Arabidopsis2022

    • Author(s)
      Hasegawa Yoko、Huarancca Reyes Thais、Uemura Tomohiro、Baral Anirban、Fujimaki Akari、Luo Yongming、Morita Yoshie、Saeki Yasushi、Maekawa Shugo、Yasuda Shigetaka、Mukuta Koki、Fukao Yoichiro、Tanaka Keiji、Nakano Akihiko、Takagi Junpei、Bhalerao Rishikesh P、Yamaguchi Junji、Sato Takeo
    • Journal Title

      The Plant Cell

      Volume: 34 Pages: 1354~1374

    • DOI

      10.1093/plcell/koac014

  • [Journal Article] CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model2022

    • Author(s)
      Tokuoka Hideki、Imae Rieko、Nakashima Hitomi、Manya Hiroshi、Masuda Chiaki、Hoshino Shunsuke、Kobayashi Kazuhiro、Lefeber Dirk J.、Matsumoto Riki、Okada Takashi、Endo Tamao、Kanagawa Motoi、Toda Tatsushi
    • Journal Title

      Nature Communications

      Volume: 13 Pages: 1265

    • DOI

      10.1038/s41467-022-29473-4

  • [Journal Article] Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis2022

    • Author(s)
      Wang Yicheng、Menon Anant K.、Maki Yuta、Liu Yi-Shi、Iwasaki Yugo、Fujita Morihisa、Guerrero Paula A.、Silva Daniel Var?’n、Seeberger Peter H.、Murakami Yoshiko、Kinoshita Taroh
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Pages: 7211

    • DOI

      10.1073/pnas.2115083119

  • [Journal Article] <i>O</i> ‐GlcNAcylation regulates β1,4‐GlcNAc‐branched <i>N</i> ‐glycan biosynthesis via the OGT/SLC35A3/GnT‐IV axis2022

    • Author(s)
      Song Wanli、Isaji Tomoya、Nakano Miyako、Liang Caixia、Fukuda Tomohiko、Gu Jianguo
    • Journal Title

      The FASEB Journal

      Volume: 36 Pages: 210

    • DOI

      10.1096/fj.202101520R

  • [Presentation] Biological roles of GOMED2023

    • Author(s)
      Shigeomi Shimizu
    • Organizer
      Organellar Zone International Symposium
    • Int'l Joint Research / Invited
  • [Remarks] オルガネラゾーン ホームページ

    • URL

      https://www.tmd.ac.jp/organellezone/index.html

  • [Funded Workshop] Organellar Zone International Symposium2023

URL: 

Published: 2023-12-25  

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